Cornelia A M van de Weg, Mateus V Thomazella, Mariana P Marmorato, Carolina A Correia, Juliana Z C Dias, Alvino Maestri, Luiz G F A B E Zanella, Natalia B Cerqueira, Alvina C Félix, Carlos H V Moreira, Renata Buccheri, Priscilla R Costa, Esper G Kallás
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Levels of Angiopoietin 2 Are Predictive for Mortality in Patients Infected With Yellow Fever Virus.
In 2018 there was a large yellow fever outbreak in São Paulo, Brazil, with a high fatality rate. Yellow fever virus can cause, among other symptoms, hemorrhage and disseminated intravascular coagulation, indicating a role for endothelial cells in disease pathogenesis. Here, we conducted a case-control study and measured markers related to endothelial damage in plasma and its association with mortality. We found that angiopoietin 2 is strongly associated with a fatal outcome and could serve as a predictive marker for mortality. This could be used to monitor severe cases and provide care to improve disease outcome.
期刊介绍:
Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.