Mônica do Amaral Silva, Lídia Audrey Rocha Valadas, Guilherme Antônio Lopes de Oliveira, Edilson Martins Rodrigues Neto, Emmanuel Arraes de Alencar Júnior, Patricia Leal Dantas Lobo, Thereza Cristina Farias Botelho Dantas, Mary Anne Medeiros Bandeira, Marta Maria de França Fonteles, Gandhi Radis Baptista
{"title":"正畸患者使用 1%巴西红蜂胶牙膏后的生物标志物：随机临床研究","authors":"Mônica do Amaral Silva, Lídia Audrey Rocha Valadas, Guilherme Antônio Lopes de Oliveira, Edilson Martins Rodrigues Neto, Emmanuel Arraes de Alencar Júnior, Patricia Leal Dantas Lobo, Thereza Cristina Farias Botelho Dantas, Mary Anne Medeiros Bandeira, Marta Maria de França Fonteles, Gandhi Radis Baptista","doi":"10.4103/jispcd.jispcd_120_23","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the salivary biomarkers and plaque index after a treatment with a propolis-contained toothpaste.</p><p><strong>Materials and methods: </strong>This is a longitudinal, randomized, double-blind study where 76 participants were randomized into two groups: Group I: Fluoridated Red Propolis toothpaste; Group II: Fluoridated toothpaste. The participants were selected in a municipality without fluoridated public water. All participants received standardized oral hygiene instructions from the same instructor for 3 daily brushings (after breakfast, after lunch, and before bed) for a period of 2 min; Saliva samples were collected before (D0) and after 28 days (D28) of treatment for analysis of pH and total protein, amylase, and IL-10. Saliva was collected in the initial consultation and on return, totaling two collections. All samples were collected under the same conditions, by the same operator and between 9:00 AM and 11:00 AM in order to minimize the influence of circadian rhythm on salivary flow.</p><p><strong>Results: </strong>On D0 and D28, the various treatments had no effect on total salivary proteins (G1: <i>P</i> = 0.0746; G2: <i>P</i> = 0.2144), and the pH stayed about the same. Additionally, there was no change in the amylase activity in G1 (<i>P</i> = 0.1877) or G2 (<i>P</i> = 0.4674). Significant decreases in G1 (<i>P</i> < 0.0001) and G2 (<i>P</i> = 0.03) were observed with IL-10. There was no statistically significant difference in the salivary flow between the BRP toothpaste-treated group (<i>P</i> = 0.172) and the commercial fluoridated toothpaste-treated group (<i>P</i> = 0.329). Compared to G2 (<i>P</i> = 0.03), G1 showed a superior decline in the plaque index (<i>P</i> = <0.0001).</p><p><strong>Conclusions: </strong>After 28 days of using the toothpastes, there were no changes in the amylase, pH, or total protein indicators. After 28 days, there was a decrease in the propolis group's IL-10 dose and plaque index.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11268535/pdf/","citationCount":"0","resultStr":"{\"title\":\"Biomarkers of Orthodontic Patients After Use of 1% Brazilian Red Propolis Toothpaste: A Randomized Clinical Study.\",\"authors\":\"Mônica do Amaral Silva, Lídia Audrey Rocha Valadas, Guilherme Antônio Lopes de Oliveira, Edilson Martins Rodrigues Neto, Emmanuel Arraes de Alencar Júnior, Patricia Leal Dantas Lobo, Thereza Cristina Farias Botelho Dantas, Mary Anne Medeiros Bandeira, Marta Maria de França Fonteles, Gandhi Radis Baptista\",\"doi\":\"10.4103/jispcd.jispcd_120_23\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>To evaluate the salivary biomarkers and plaque index after a treatment with a propolis-contained toothpaste.</p><p><strong>Materials and methods: </strong>This is a longitudinal, randomized, double-blind study where 76 participants were randomized into two groups: Group I: Fluoridated Red Propolis toothpaste; Group II: Fluoridated toothpaste. The participants were selected in a municipality without fluoridated public water. All participants received standardized oral hygiene instructions from the same instructor for 3 daily brushings (after breakfast, after lunch, and before bed) for a period of 2 min; Saliva samples were collected before (D0) and after 28 days (D28) of treatment for analysis of pH and total protein, amylase, and IL-10. Saliva was collected in the initial consultation and on return, totaling two collections. All samples were collected under the same conditions, by the same operator and between 9:00 AM and 11:00 AM in order to minimize the influence of circadian rhythm on salivary flow.</p><p><strong>Results: </strong>On D0 and D28, the various treatments had no effect on total salivary proteins (G1: <i>P</i> = 0.0746; G2: <i>P</i> = 0.2144), and the pH stayed about the same. Additionally, there was no change in the amylase activity in G1 (<i>P</i> = 0.1877) or G2 (<i>P</i> = 0.4674). Significant decreases in G1 (<i>P</i> < 0.0001) and G2 (<i>P</i> = 0.03) were observed with IL-10. There was no statistically significant difference in the salivary flow between the BRP toothpaste-treated group (<i>P</i> = 0.172) and the commercial fluoridated toothpaste-treated group (<i>P</i> = 0.329). Compared to G2 (<i>P</i> = 0.03), G1 showed a superior decline in the plaque index (<i>P</i> = <0.0001).</p><p><strong>Conclusions: </strong>After 28 days of using the toothpastes, there were no changes in the amylase, pH, or total protein indicators. After 28 days, there was a decrease in the propolis group's IL-10 dose and plaque index.</p>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2024-06-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11268535/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/jispcd.jispcd_120_23\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/5/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jispcd.jispcd_120_23","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Biomarkers of Orthodontic Patients After Use of 1% Brazilian Red Propolis Toothpaste: A Randomized Clinical Study.
Aim: To evaluate the salivary biomarkers and plaque index after a treatment with a propolis-contained toothpaste.
Materials and methods: This is a longitudinal, randomized, double-blind study where 76 participants were randomized into two groups: Group I: Fluoridated Red Propolis toothpaste; Group II: Fluoridated toothpaste. The participants were selected in a municipality without fluoridated public water. All participants received standardized oral hygiene instructions from the same instructor for 3 daily brushings (after breakfast, after lunch, and before bed) for a period of 2 min; Saliva samples were collected before (D0) and after 28 days (D28) of treatment for analysis of pH and total protein, amylase, and IL-10. Saliva was collected in the initial consultation and on return, totaling two collections. All samples were collected under the same conditions, by the same operator and between 9:00 AM and 11:00 AM in order to minimize the influence of circadian rhythm on salivary flow.
Results: On D0 and D28, the various treatments had no effect on total salivary proteins (G1: P = 0.0746; G2: P = 0.2144), and the pH stayed about the same. Additionally, there was no change in the amylase activity in G1 (P = 0.1877) or G2 (P = 0.4674). Significant decreases in G1 (P < 0.0001) and G2 (P = 0.03) were observed with IL-10. There was no statistically significant difference in the salivary flow between the BRP toothpaste-treated group (P = 0.172) and the commercial fluoridated toothpaste-treated group (P = 0.329). Compared to G2 (P = 0.03), G1 showed a superior decline in the plaque index (P = <0.0001).
Conclusions: After 28 days of using the toothpastes, there were no changes in the amylase, pH, or total protein indicators. After 28 days, there was a decrease in the propolis group's IL-10 dose and plaque index.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
