BASEHIT 打出全垒打：阐明病原体与宿主之间的相互作用。

IF 7 1区医学 Q1 PARASITOLOGY

Trends in parasitology Pub Date : 2024-09-01 Epub Date: 2024-07-24 DOI:10.1016/j.pt.2024.07.004

Kelly A Brayton, Jason M Park

引用次数: 0

摘要

最近，哈特及其同事利用一种被称为 BASEHIT（细菌选择以高通量阐明宿主与微生物之间的相互作用）的技术，对包含 3324 种人类外显蛋白的酵母展示文库和 82 种病原体样本进行了筛选，重点筛选了病媒传播的病原体，确定了 1303 种推测的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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BASEHIT scores home run: elucidates pathogen-host interactions.

In a tour de force, Hart and colleagues recently used a technique known as BASEHIT (bacterial selection to elucidate host-microbe interactions in high throughput) to screen a yeast display library containing 3324 curated human exoproteins with 82 pathogen samples, focusing on vector-borne pathogens, to identify 1303 putative interactions.

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来源期刊

Trends in parasitology 医学-寄生虫学

CiteScore

14.00

自引率

3.10%

发文量

148

审稿时长

6-12 weeks

期刊介绍： Since its inception as Parasitology Today in 1985, Trends in Parasitology has evolved into a highly esteemed review journal of global significance, reflecting the importance of medical and veterinary parasites worldwide. The journal serves as a hub for communication among researchers across all disciplines of parasitology, encompassing endoparasites, ectoparasites, transmission vectors, and susceptible hosts. Each monthly issue of Trends in Parasitology offers authoritative, cutting-edge, and yet accessible review articles, providing a balanced and comprehensive overview, along with opinion pieces offering personal and novel perspectives. Additionally, the journal publishes a variety of short articles designed to inform and stimulate thoughts in a lively and widely-accessible manner. These include Science & Society (discussing the interface between parasitology and the general public), Spotlight (highlighting recently published research articles), Forum (presenting single-point hypotheses), Parasite/Vector of the Month (featuring a modular display of the selected species), Letter (providing responses to recent articles in Trends in Parasitology), and Trendstalk (conducting interviews). Please note that the journal exclusively publishes literature reviews based on published data, with systematic reviews, meta-analysis, and unpublished primary research falling outside our scope.