失忆性轻度认知障碍患者一年内皮层下纵向萎缩的模式及其对认知能力的影响:一项初步研究。

IF 1.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Turkish Journal of Medical Sciences Pub Date : 2024-03-11 eCollection Date: 2024-01-01 DOI:10.55730/1300-0144.5826
Berrin Çavuşoğlu, Duygu Hünerli, Derya Durusu Emek Savaş, Görsev Yener, Emel Ada
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引用次数: 0

摘要

背景/目的:失忆性轻度认知障碍(aMCI)是痴呆症的一个危险因素,因此,了解aMCI患者的特定脑萎缩模式很有意义。我们旨在确定皮层下结构的纵向萎缩模式及其对 aMCI 患者认知能力的影响:研究对象包括 20 名 aMCI 患者和 20 名人口统计学匹配的健康对照者,他们均接受了基线和纵向结构磁共振成像扫描以及神经心理学评估。采用 FIRST 算法(FMRIB 的集成注册和分割工具)获得皮层下结构(丘脑、普鲁门、尾状核、伏隔核、球状苍白球、海马和杏仁核)的体积。研究还评估了体积与认知能力之间的相关性:与健康对照组相比,aMCI患者的海马(p = 0.001)、伏隔核(p = 0.003)和丘脑(p = 0.003)在基线时出现皮层下萎缩。丘脑、伏隔核和海马的基线体积与记忆力、丘脑与视觉空间技能有显著关联。丘脑、伏隔核和海马可为 aMCI 提供额外的诊断信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Patterns of longitudinal subcortical atrophy over one year in amnestic mild cognitive impairment and its impact on cognitive performance: a preliminary study.

Background/aim: Amnestic mild cognitive impairment (aMCI) is a risk factor for dementia, and thus, it is of interest to enlighten specific brain atrophy patterns in aMCI patients. We aim to define the longitudinal atrophy pattern in subcortical structures and its effect on cognition in patients with aMCI.

Materials and methods: Twenty patients with aMCI and 20 demographically matched healthy controls with baseline and longitudinal structural magnetic resonance imaging scans and neuropsychological assessments were studied. The algorithm FIRST (FMRIB's integrated registration and segmentation tool) was used to obtain volumes of subcortical structures (thalamus, putamen, caudate nucleus, nucleus accumbens, globus pallidus, hippocampus, and amygdala). Correlations between volumes and cognitive performance were assessed.

Results: Compared with healthy controls, aMCI demonstrated subcortical atrophies in the hippocampus (p = 0.001), nucleus accumbens (p = 0.003), and thalamus (p = 0.003) at baseline. Significant associations were found for the baseline volumes of the thalamus, nucleus accumbens, and hippocampus with memory, the thalamus with visuospatial skills.

Conclusion: aMCI demonstrated subcortical atrophies associated with cognitive deficits. The thalamus, nucleus accumbens, and hippocampus may provide additional diagnostic information for aMCI.

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来源期刊
Turkish Journal of Medical Sciences
Turkish Journal of Medical Sciences 医学-医学:内科
CiteScore
4.60
自引率
4.30%
发文量
143
审稿时长
3-8 weeks
期刊介绍: Turkish Journal of Medical sciences is a peer-reviewed comprehensive resource that provides critical up-to-date information on the broad spectrum of general medical sciences. The Journal intended to publish original medical scientific papers regarding the priority based on the prominence, significance, and timeliness of the findings. However since the audience of the Journal is not limited to any subspeciality in a wide variety of medical disciplines, the papers focusing on the technical  details of a given medical  subspeciality may not be evaluated for publication.
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