原发性胸腺癌的临床特征和预后:一项单中心回顾性分析。

IF 2.3 3区 医学 Q3 ONCOLOGY
Thoracic Cancer Pub Date : 2024-08-01 Epub Date: 2024-07-25 DOI:10.1111/1759-7714.15407
Qian Hong, Rui Han, Chen Chen, Fuquan Wang, Sining Zhang, Chenguang Zhao, Fang Li, Juwei Mu, Jiagen Li
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引用次数: 0

摘要

背景:原发性胸腺癌(PTAC原发性胸腺癌(PTAC)是一种极为罕见的疾病,预后较差。在本研究中,我们试图分析 PTAC 患者的临床特征和预后因素:本研究共纳入2000年1月至2019年1月在本中心接受治疗的14例PTAC患者。我们回顾性地收集了患者的性别、年龄、吸烟史、癌症家族史、合并症、症状、影像学检查、血清肿瘤标志物水平、肿瘤、结节、转移(TNM)分期以及治疗记录等信息。随访信息通过电话访谈或门诊访问获得。通过单变量和多变量考克斯回归分析,研究与生存相关的临床病理因素:14名PTAC患者中,男性5人,女性9人,平均年龄(48.7±9.3)岁。23.1%的患者有吸烟史。患者的临床症状无特异性,7 名患者的血清肿瘤标志物水平升高。9名患者接受了手术治疗,其中只有4人接受了R0切除术。14名患者的中位生存时间为16.0个月,1年、3年和5年生存率分别为57.1%、35.7%和21.4%。TNM分期被认为是PTAC患者的独立预后因素(I-IIIA期与IV期的中位生存时间分别为44.0个月和9.0个月,P = 0.002):结论:PTAC是一种侵袭性很强的恶性肿瘤,预后较差。结论:PTAC是一种侵袭性很强的恶性肿瘤,预后很差。手术治疗是可行的,但R0切除术具有挑战性。TNM分期与患者的生存期密切相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical characteristics and prognosis of primary thymic adenocarcinoma: A single-center retrospective analysis.

Background: Primary thymic adenocarcinoma (PTAC) is an extremely rare disease with a poor prognosis. In the present study, we sought to analyze the clinical characteristics and prognostic factors of patients with PTAC.

Methods: A total of 14 patients with PTAC treated at our center from January 2000 to January 2019 were included in this study. We retrospectively collected information on sex, age, history of smoking, family history of cancer, comorbidities, symptoms, imaging tests, serum tumor marker levels, tumor, node, metastasis (TNM) staging, and treatment records. Follow-up information was obtained by telephone interviews or outpatient clinic visit. Univariate and multivariate Cox regression analyses were performed to investigate the clinicopathological factors associated with survival.

Results: Among 14 patients with PTAC, there were five males and nine females, with an average age of 48.7 ± 9.3 years. A total of 23.1% of the patients had a history of smoking. The clinical symptoms of the patients were nonspecific and seven patients had elevated levels of serum tumor markers. Surgery was performed for nine patients, among which only four received R0 resection. The median survival time of the 14 patients was 16.0 months, and the 1-, 3- and 5-year survival rates were 57.1%, 35.7% and 21.4%, respectively. TNM stage was identified as an independent prognostic factor for PTAC patients (the median survival time of stage I-IIIA vs. stage IV was 44.0 months vs. 9.0 months, p = 0.002).

Conclusions: PTAC is highly aggressive malignancy with poor prognosis. Surgical treatment is feasible, but R0 resection is challenging. TNM staging is significantly associated with patient survival.

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来源期刊
Thoracic Cancer
Thoracic Cancer ONCOLOGY-RESPIRATORY SYSTEM
CiteScore
5.20
自引率
3.40%
发文量
439
审稿时长
2 months
期刊介绍: Thoracic Cancer aims to facilitate international collaboration and exchange of comprehensive and cutting-edge information on basic, translational, and applied clinical research in lung cancer, esophageal cancer, mediastinal cancer, breast cancer and other thoracic malignancies. Prevention, treatment and research relevant to Asia-Pacific is a focus area, but submissions from all regions are welcomed. The editors encourage contributions relevant to prevention, general thoracic surgery, medical oncology, radiology, radiation medicine, pathology, basic cancer research, as well as epidemiological and translational studies in thoracic cancer. Thoracic Cancer is the official publication of the Chinese Society of Lung Cancer, International Chinese Society of Thoracic Surgery and is endorsed by the Korean Association for the Study of Lung Cancer and the Hong Kong Cancer Therapy Society. The Journal publishes a range of article types including: Editorials, Invited Reviews, Mini Reviews, Original Articles, Clinical Guidelines, Technological Notes, Imaging in thoracic cancer, Meeting Reports, Case Reports, Letters to the Editor, Commentaries, and Brief Reports.
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