抗肿瘤孕激素活性：细胞抑制作用和免疫反应

IF 2.1 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Steroids Pub Date : 2024-07-22 DOI:10.1016/j.steroids.2024.109474

T. Pavlik , E. Konchekov , N. Shimanovskii

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引用次数: 0

摘要

孕激素可用于治疗某些对激素敏感的肿瘤。本综述讨论了孕激素对肿瘤细胞的作用机制、孕酮及其类似物对不同类型肿瘤的作用差异，以及孕激素对抗肿瘤免疫反应的影响。孕激素具有细胞抑制作用，但同时会抑制抗肿瘤免疫反应，从而促进肿瘤细胞的增殖和转移。地诺孕酮、醋酸甲地孕酮和左炔诺孕酮等孕激素能增强 NK 细胞的活性，而 NK 细胞在机体对抗肿瘤细胞的过程中发挥着重要作用。使用现有的孕激素和开发具有孕激素活性的新药可能会为肿瘤治疗带来希望。

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Antitumor progestins activity: Cytostatic effect and immune response

Progestins are used to treat some hormone-sensitive tumors. This review discusses the mechanisms of progestins’ effects on tumor cells, the differences in the effects of progesterone and its analogs on different tumor types, and the influence of progestins on the antitumor immune response. Progestins cause a cytostatic effect, but at the same time they can suppress the antitumor immune response, and this can promote the proliferation and metastasis of tumor cells. Such progestins as dienogest, megestrol acetate and levonorgestrel increase the activity of NK-cells, which play a major role in the body’s fight against tumor cells. The use of existing progestins and the development of new drugs with gestagenic activity may hold promise in oncotherapy.

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来源期刊

Steroids 医学-内分泌学与代谢

CiteScore

5.10

自引率

3.70%

发文量

120

审稿时长

73 days

期刊介绍： STEROIDS is an international research journal devoted to studies on all chemical and biological aspects of steroidal moieties. The journal focuses on both experimental and theoretical studies on the biology, chemistry, biosynthesis, metabolism, molecular biology, physiology and pharmacology of steroids and other molecules that target or regulate steroid receptors. Manuscripts presenting clinical research related to steroids, steroid drug development, comparative endocrinology of steroid hormones, investigations on the mechanism of steroid action and steroid chemistry are all appropriate for submission for peer review. STEROIDS publishes both original research and timely reviews. For details concerning the preparation of manuscripts see Instructions to Authors, which is published in each issue of the journal.