性腺切除术对南非一家兽医学术医院中 6 个月及以上犬类巴贝西亚原虫病发病率和严重巴贝西亚原虫病风险的影响:病例对照和回顾性队列研究。

IF 2.2 2区 农林科学 Q1 VETERINARY SCIENCES
Darryn L. Knobel , Josef Hanekom , Maria C. van den Bergh , Andrew L. Leisewitz
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引用次数: 0

摘要

狗的性腺切除术与各种非传染性健康状况的风险变化有关,但很少有研究探讨其对传染病结果的影响。我们的研究目的是估算性腺切除术对巴贝虫诊断发病率的因果影响,以及对2013年至2020年期间在南非一家兽医学术医院就诊的6个月及以上犬只中确诊病例中严重巴贝虫病风险的因果影响。为了估算性腺切除术对狗巴贝西亚原虫病诊断发病率的影响,我们对通过医院初级保健服务就诊的狗进行了发病密度抽样病例对照研究,并对性别、年龄、品种类别和体重进行了调整。我们确定了 811 个病例,并选择了 3244 个时间匹配的对照组。为了估算性腺切除术对巴贝西亚原虫病犬疾病严重程度的影响,我们对所有确诊为巴贝西亚原虫病的犬只进行了回顾性队列研究(923 只),其中包括这 811 例病例和另外 112 只转诊到医院的犬只,同样对性别、年龄、犬种类别和体重进行了调整。性腺切除术大大降低了巴贝西亚原虫病的发病率(总效应发病率比 [IRR] 0.5;95 % 置信区间 [CI] 0.41-0.60),并降低了确诊病犬患严重巴贝西亚原虫病的风险(总效应风险比 [RR] 0.72;95 % 置信区间 [CI] 0.60-0.86)。临界点敏感性分析表明,这些效应估计值对未测量的混杂偏差具有稳健性。没有证据表明性腺切除术的效果会因性别而改变,男性和女性对两种结果的效果估计值在性质上相似。与女性相比,男性巴贝西亚原虫病的发病率更高(IRR 1.74;95 % CI 1.49-2.04),患严重疾病的风险更高(RR 1.12;95 % CI 0.98-1.28)。总之,我们的研究表明,性腺切除术对 6 月龄及以上公犬和母犬巴贝西亚原虫病的发病率和严重程度都有很强的保护作用,并为关于性腺切除术对这一人群的总体风险和益处的讨论提供了重要证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of gonadectomy on the incidence rate of babesiosis and the risk of severe babesiosis in dogs aged 6 months and older at a veterinary academic hospital in South Africa: A case-control and retrospective cohort study

Gonadectomy in dogs is associated with changes in risks of a variety of non-infectious health conditions, but few studies have examined its effects on infectious disease outcomes. The objectives of our study were to estimate the causal effect of gonadectomy on the incidence rate of babesiosis diagnosis, and on the risk of severe babesiosis in diagnosed cases, in dogs 6 months and older seen at a veterinary academic hospital in South Africa from 2013 through 2020. To estimate the effect of gonadectomy on the incidence rate of babesiosis diagnosis in dogs, we conducted a case-control study with incidence density sampling of dogs seen through the hospital’s primary care service, adjusting for sex, age, breed category and weight. We identified 811 cases and selected 3244 time-matched controls. To estimate the effect of gonadectomy on disease severity in dogs with babesiosis, we conducted a retrospective cohort study among all dogs with a diagnosis of babesiosis (n=923), including these 811 cases and a further 112 referred to the hospital, also adjusting for sex, age, breed category and weight. Gonadectomy substantially reduced the incidence rate of babesiosis (total effect incidence rate ratio [IRR] 0.5; 95 % confidence interval [CI] 0.41–0.60) and the risk of severe babesiosis among diagnosed dogs (total effect risk ratio [RR] 0.72; 95 % CI 0.60–0.86). Tipping point sensitivity analysis shows that these effect estimates are robust to unmeasured confounding bias. There was no evidence for modification of the effect of gonadectomy by sex, with effect estimates qualitatively similar for males and females for both outcomes. Compared to females, males had a higher incidence rate of babesiosis (IRR 1.74; 95 % CI 1.49–2.04) and a higher risk of severe disease (RR 1.12; 95 % CI 0.98–1.28). In conclusion, our study shows a robust protective effect of gonadectomy on the incidence and severity of babesiosis in both male and female dogs 6 months of age and older, and contributes important evidence to the debate on the overall risks and benefits of gonadectomy to dogs in this population.

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来源期刊
Preventive veterinary medicine
Preventive veterinary medicine 农林科学-兽医学
CiteScore
5.60
自引率
7.70%
发文量
184
审稿时长
3 months
期刊介绍: Preventive Veterinary Medicine is one of the leading international resources for scientific reports on animal health programs and preventive veterinary medicine. The journal follows the guidelines for standardizing and strengthening the reporting of biomedical research which are available from the CONSORT, MOOSE, PRISMA, REFLECT, STARD, and STROBE statements. The journal focuses on: Epidemiology of health events relevant to domestic and wild animals; Economic impacts of epidemic and endemic animal and zoonotic diseases; Latest methods and approaches in veterinary epidemiology; Disease and infection control or eradication measures; The "One Health" concept and the relationships between veterinary medicine, human health, animal-production systems, and the environment; Development of new techniques in surveillance systems and diagnosis; Evaluation and control of diseases in animal populations.
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