年龄增长与鸦片制剂的致命使用。

IF 1.5 4区 医学 Q1 LAW
Jeremy Ws Hunter, Corinna van den Heuvel, Lilli Stephenson, Lauren Elborough, Roger W Byard
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引用次数: 0

摘要

阿片类药物滥用是全世界与毒品有关的发病率和死亡率的主要原因。有研究表明,澳大利亚阿片类药物使用者的年龄正在上升。为了在当地人群中进一步评估这一现象,我们研究了南澳大利亚州阿德莱德市南澳大利亚法医学中心的毒理学和病理学病例档案,其中包括 2000 年至 2019 年期间所有阿片类药物致死病例(n = 499;男:女为 2.3:1;年龄范围为 18-91 岁,中位年龄为 42 岁)。阿片类药物死亡病例的中位年龄显著增加了约16岁(p = 0.007,R2 = 0.34),45-54岁和55-64岁年龄组的死亡总人数显著增加(p = 0.009,R2 = 0.32)(p = R2 = 0.54)。海洛因过量致死的中位年龄最低(39 岁,n = 184),曲马多中毒致死的中位年龄最高(50.5 岁,n = 32)。在致死性过量案例中,阿片类药物使用者的人口统计学特征最近发生了变化,涉及老龄化人群。法医和临床从业人员应了解某些年龄较大的人滥用阿片类药物的情况,因为这可能会加剧这一群体中与年龄有关的慢性疾病的影响,并/或导致死亡。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Increasing age and lethal opiate use.

Opioid abuse is a leading cause of drug-related morbidity and mortality worldwide. It has been suggested that the age of opiate users in Australia is rising. To evaluate this further in a local population, toxicology and pathology case files from Forensic Science SA, Adelaide, South Australia, were examined for all cases with lethal opioid levels from 2000 to 2019 (n = 499; M:F 2.3:1; age range 18-91 years, median age 42 years). The median age of opiate deaths increased significantly by approximately 16 years (p = 0.007, R2 = 0.34) with a significant increase in total deaths in the 45-54 years and 55-64 years age groups (p = 0.009, R2 = 0.32) (p = < 0.001, R2 = 0.54). Deaths due to heroin overdose showed the lowest median age (39 years, n = 184), with deaths from tramadol toxicity having the highest (50.5 years, n = 32). Recent changes in the demographic profile of opioid users in cases of lethal overdose involve an aging population. Forensic and clinical practitioners should be aware of significant opioid abuse in certain individuals at older ages as this raises the possibility that this may exacerbate the effects of age-related chronic diseases in this group and/or contribute to fatalities.

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来源期刊
Medicine, Science and the Law
Medicine, Science and the Law 医学-医学:法
CiteScore
2.90
自引率
6.70%
发文量
53
审稿时长
>12 weeks
期刊介绍: Medicine, Science and the Law is the official journal of the British Academy for Forensic Sciences (BAFS). It is a peer reviewed journal dedicated to advancing the knowledge of forensic science and medicine. The journal aims to inform its readers from a broad perspective and demonstrate the interrelated nature and scope of the forensic disciplines. Through a variety of authoritative research articles submitted from across the globe, it covers a range of topical medico-legal issues. The journal keeps its readers informed of developments and trends through reporting, discussing and debating current issues of importance in forensic practice.
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