对约旦一家三级教学医院药物警戒数据登记处的回顾性分析。

IF 3.3 Q1 HEALTH POLICY & SERVICES
Journal of Pharmaceutical Policy and Practice Pub Date : 2024-07-23 eCollection Date: 2024-01-01 DOI:10.1080/20523211.2024.2378461
Khawla Abu Hammour, Faris El-Dahiyat, Rund Hyari, Sara Salameh, Qusai Manaseer, Rana Abu Farha, Adnan Abu Hammour, Mohammed Zawiah
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引用次数: 0

摘要

目的:本研究旨在分析约旦大学医院的药物不良反应(ADR)报告模式:本研究旨在分析约旦大学医院的药物不良反应(ADR)报告模式,以加强药物警戒实践:对 2023 年 2 月至 8 月的 ADR 数据进行了回顾性分析。数据包括患者人口统计学特征、涉及药物、严重程度标准和受影响的系统器官类别:在分析的1340份不良反应报告中,女性占67.4%,18岁至65岁以下的成年人占95.3%。大多数药物不良反应并不严重,仅有 2.1%导致住院或住院时间延长。最常报告的不良反应包括腹痛(8.3%)、恶心(6.9%)、头痛(4.7%)和头晕(4.7%)。值得注意的是,心血管系统药物(16.4%)和消化道及新陈代谢药物(16.2%)通常与不良反应有关,其次是肌肉骨骼系统药物(9.0%)。此外,在所有报告的药物中,99.9%被认为是疑似药物不良反应(疑似药物不良反应病例包括经因果关系评估后被评为 "可能"、"可能 "或 "确定 "的患者治疗病例(2017年由世界卫生组织-联合国医管局系统评定),口服给药是主要途径(89.5%):研究强调,与历史数据相比,研究期间的 ADR 报告明显增加,这表明医疗保健提供者的认识和理解有所提高。加强药物警戒实践,尤其是药剂师的参与,对于有效发现和报告 ADR 至关重要。有必要进一步调查导致严重 ADRs 流行的因素,以改善患者的安全和健康状况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A retrospective analysis of the pharmacovigilance data registry in a tertiary teaching hospital in Jordan.

Objectives: The study aims to analyse adverse drug reaction (ADR) reporting patterns at Jordan University Hospital to enhance pharmacovigilance practices.

Methods: Retrospective analysis of ADR data from February to August 2023 was conducted. Data included patient demographics, drugs implicated, seriousness criteria, and system organ classes affected.

Results: Among 1340 ADR reports analysed, females accounted for 67.4% of cases, with adults aged 18 to less than 65 years comprising 95.3% of reports. The majority of ADRs were non-serious, with only 2.1% resulting in hospitalisation or prolonged hospital stay. The most frequently reported ADRs included abdominal pain (8.3%), nausea (6.9%), headache (4.7%), and dizziness (4.7%). Notably, cardiovascular system drugs (16.4%) and alimentary tract and metabolism drugs (16.2%) were commonly associated with ADRs, followed by musculoskeletal system drugs (9.0%). Additionally, among all reported drugs, 99.9% were considered suspects, (suspected ADR cases include patient treatment cases for which a likelihood of being related to a drug therapy was scored as 'possible', 'probable', or 'certain' after causality assessment (by the WHO-UMC system in 2017), with oral administration being the predominant route (89.5%).

Conclusion: The study highlights a notable increase in ADR reporting during the study period compared to historical data, indicating heightened awareness and understanding among healthcare providers. Enhanced pharmacovigilance practices, particularly involving pharmacists, are essential for detecting and reporting ADRs effectively. Further investigation into factors contributing to prevalent serious ADRs is warranted to improve patient safety and health outcomes.

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来源期刊
Journal of Pharmaceutical Policy and Practice
Journal of Pharmaceutical Policy and Practice Health Professions-Pharmacy
CiteScore
4.70
自引率
9.50%
发文量
81
审稿时长
14 weeks
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