阻塞性睡眠呼吸暂停和交感神经系统对心脏健康的影响:全面回顾。

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Antonino Maniaci, Salvatore Lavalle, Federica Maria Parisi, Marco Barbanti, Salvatore Cocuzza, Giannicola Iannella, Giuseppe Magliulo, Annalisa Pace, Mario Lentini, Edoardo Masiello, Luigi La Via
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引用次数: 0

摘要

睡眠呼吸暂停是一种与心血管疾病风险升高有关的普遍病症。这篇综述探讨了心脏风险、交感神经系统和睡眠呼吸暂停之间的联系。高血压、心律失常、心肌梗塞和心力衰竭风险的增加在睡眠呼吸暂停的病理生理学及其对交感神经激活的影响中得到了强调。考虑氧化应激、炎症、内皮功能障碍和自律神经失衡等潜在过程也很重要,这些过程可能将睡眠呼吸暂停诱发的交感神经激活与心脏风险联系在一起。本研究的目的是加深人们对交感神经活动、心脏风险和睡眠呼吸暂停之间错综复杂的联系的理解,从而为减少睡眠呼吸暂停对心血管的影响提供创新的诊断和治疗方法。本研究旨在通过综合现有研究,阐明心血管健康与睡眠呼吸暂停之间的复杂关系,并强调交感神经系统在调节这种关系中所起的关键作用。我们的深入调查可能会产生重要的治疗效果,从而指导制定有针对性的疗法,改善睡眠呼吸暂停患者的心血管状况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of Obstructive Sleep Apnea and Sympathetic Nervous System on Cardiac Health: A Comprehensive Review.

A prevalent condition linked to an elevated risk of cardiovascular disease is sleep apnea. This review examines the connections between cardiac risk, the sympathetic nervous system, and sleep apnea. The increased risk of hypertension, arrhythmias, myocardial infarction, and heart failure was highlighted in the pathophysiology of sleep apnea and its effect on sympathetic activation. It is also important to consider potential processes such as oxidative stress, inflammation, endothelial dysfunction, and autonomic imbalance that may relate sleep apnea-induced sympathetic activation to cardiac risk. With implications for creating innovative diagnostic and treatment approaches to lessen the cardiovascular effects of sleep apnea, the goal of this investigation is to improve the understanding of the intricate link between sympathetic activity, cardiac risk, and sleep apnea. This study aimed to clarify the complex relationship between cardiovascular health and sleep apnea by synthesizing the available research and highlighting the crucial role played by the sympathetic nervous system in moderating this relationship. Our thorough investigation may have important therapeutic ramifications that will direct the creation of focused therapies to enhance cardiovascular outcomes in sleep apnea sufferers.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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