糖尿病视网膜病变与长非编码 RNA CDKN2B-AS1 基因多态性的遗传关联

IF 1.4 4区医学 Q3 OPHTHALMOLOGY

European Journal of Ophthalmology Pub Date : 2025-03-01 Epub Date: 2024-07-26 DOI:10.1177/11206721241266704

Yen-Po Yao, Hsiang-Wen Chien, Kai Wang, Yi-Sun Yang, Shih-Chi Su, Lun-Ching Chang, Hung-Yu Lin, Shun-Fa Yang

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引用次数: 0

摘要

目的：我们试图检测细胞周期蛋白依赖性激酶抑制剂 2B 反义 RNA 1（CDKN2B-AS1）基因多态性对糖尿病视网膜病变（DR）易感性的影响：方法：在280例DR患者和455例无DR的糖尿病对照者中检测了CDKN2B-AS1基因的5个单核苷酸多态性（SNPs），即rs564398、rs1333048、rs1537373、rs2151280和rs8181047：在检测的这些位点中，我们发现 rs2151280（AG 和 GG；AOR，1.613；95% CI，1.040-2.501；p = 0.033）中至少有一个多态等位基因（G）的糖尿病携带者更易患增殖性 DR，而非增殖性 DR。在 rs2151280 的多态等位基因（G）（GG；AOR，2.194；95% CI，1.117-4.308；p = 0.023）的同基因人中，这种与增殖性 DR 发病风险的遗传关联进一步加强。我们发现，rs2151280 的多态等位基因 (G) 与增殖性 DR 患者有显著关联（OR，1.503；95% CI，1.112-2.033；p = 0.008），但与整个 DR 或非增殖性 DR 组没有关联。此外，与不携带 rs2151280 多态等位基因（AA）的患者相比，至少携带一个 rs2151280 多态等位基因（AG + GG）的 DR 患者的肾小球滤过率和高密度脂蛋白胆固醇水平较低，这揭示了 rs2151280 在糖尿病肾脏和心血管并发症中的促进作用：综上所述，我们的研究结果表明 CDKN2B-AS1 基因多态性对 DR 的进展有影响。

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Genetic association of diabetic retinopathy with long noncoding RNA CDKN2B-AS1 gene polymorphism.

Aim: We attempted to test the influences of cyclin dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1) gene polymorphisms on the susceptibility to Diabetic retinopathy (DR).

Methods: Five single-nucleotide polymorphisms (SNPs) of the CDKN2B-AS1 gene, rs564398, rs1333048, rs1537373, rs2151280, and rs8181047 were examined in 280 DR cases and 455 DR-free diabetic controls.

Results: Among these loci tested, we demonstrated that diabetic carriers of at least one polymorphic allele (G) of rs2151280 (AG and GG; AOR, 1.613; 95% CI, 1.040-2.501; p = 0.033) are more susceptible to proliferative DR but not non-proliferative DR. This genetic association with the risk of developing proliferative DR was further strengthened in homozygotes for the polymorphic allele (G) of rs2151280 (GG; AOR, 2.194; 95% CI, 1.117-4.308; p = 0.023). We detected a significant association of the polymorphic allele (G) of rs2151280 with proliferative DR patients (OR, 1.503; 95% CI, 1.112-2.033; p = 0.008) but not with the entire DR or non-proliferative DR group. Moreover, as compared to those who do not possess the polymorphic allele of rs2151280 (AA), DR patients carrying at least one polymorphic allele of rs2151280 (AG + GG) exhibited a lower glomerular filtration rate and HDL cholesterol level, revealing a promotive role of rs2151280 in renal and cardiovascular complications of diabetes.

Conclusion: Taken together, our findings implicate an impact of CDKN2B-AS1 gene polymorphisms on the progression of DR.

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来源期刊

European Journal of Ophthalmology 医学-眼科学

CiteScore

3.60

自引率

0.00%

发文量

372

审稿时长

3-8 weeks

期刊介绍： The European Journal of Ophthalmology was founded in 1991 and is issued in print bi-monthly. It publishes only peer-reviewed original research reporting clinical observations and laboratory investigations with clinical relevance focusing on new diagnostic and surgical techniques, instrument and therapy updates, results of clinical trials and research findings.