钠葡萄糖转运体-2 抑制剂对血脂、钙化性动脉粥样硬化和骨密度的复杂作用。

IF 3.8 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Current opinion in lipidology Pub Date : 2024-10-01 Epub Date: 2024-07-18 DOI:10.1097/MOL.0000000000000942
Stuti Pradhan, Sophia Kalanski, Yin Tintut, Linda L Demer
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引用次数: 0

摘要

综述目的:钠-葡萄糖共转运体-2(SGLT2)抑制剂可降低肾脏对葡萄糖的重吸收,因此被用于治疗 2 型糖尿病患者。临床试验不约而同地显示,SGLT2 抑制剂也有益于心力衰竭患者。本综述探讨了 SGLT2 抑制剂对心血管疾病和骨骼健康其他方面的影响:在一些临床研究和临床前研究中发现,SGLT2 抑制剂可降低血清中游离脂肪酸和甘油三酯的水平。它们对总胆固醇、低密度脂蛋白胆固醇和心脏功能的影响也各不相同。不过,SGLT2 抑制剂可减少肝脏、肾脏和心脏中的脂质蓄积,并改变脂质代谢基因的表达。对腹部脂肪库中游离脂肪酸摄取的影响取决于脂肪组织的位置。在雄性小鼠(而非雌性小鼠)中,SGLT2 抑制剂可减少动脉粥样硬化病变和主动脉钙沉积。摘要:研究表明,SGLT2 抑制剂可减少组织脂质积累,并以性别依赖的方式减少动脉粥样硬化和血管钙化。然而,它们对血脂水平和骨骼健康的影响非常复杂,仍有待确定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Complex actions of sodium glucose transporter-2 inhibitors on lipids, calcific atherosclerosis, and bone density.

Purpose of review: Inhibitors of sodium-glucose cotransporter-2 (SGLT2) lower renal glucose reabsorption and, thus, are used to treat patients with type 2 diabetes mellitus. Clinical trials coincidentally showed that SGLT2 inhibitors also benefitted patients with heart failure. This review explores the impact of SGLT2 inhibitors on other aspects of cardiovascular disease and skeletal health.

Recent findings: In some, but not all, clinical and preclinical studies, SGLT2 inhibitors are found to reduce serum levels of free fatty acids and triglycerides. Their effects on total and low-density lipoprotein cholesterol and cardiac function also vary. However, SGLT2 inhibitors reduce lipid accumulation in the liver, kidney, and heart, and alter expression of lipid metabolism genes. Effects on free fatty acid uptake in abdominal fat depots depend on the location of adipose tissue. In male, but not female, mice, SGLT2 inhibitors reduce the atherosclerotic lesions and aortic calcium deposition. With respect to skeletal health, recent literature has reported conflicting associations with the risks of fracture and amputation.

Summary: Studies suggest that SGLT2 inhibitors reduce tissue lipid accumulation, and in a sex-dependent manner, atherosclerosis and vascular calcification. However, their effects on lipid levels and bone health are complex and remain to be established.

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来源期刊
Current opinion in lipidology
Current opinion in lipidology 医学-内分泌学与代谢
CiteScore
6.70
自引率
4.50%
发文量
64
审稿时长
6-12 weeks
期刊介绍: With its easy-to-digest reviews on important advances in world literature, Current Opinion in Lipidology offers expert evaluation on a wide range of topics from six key disciplines including nutrition and metabolism, genetics and molecular biology, and hyperlipidaemia and cardiovascular disease. Published bimonthly, each issue covers in detail the most pertinent advances in these fields from the previous year. This is supplemented by a section of Bimonthly Updates, which deliver an insight into new developments at the cutting edge of the disciplines covered in the journal.
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