Linda Tognetti, Simone Cappilli, Francesca Falcinelli, Simone Soglia, Francesco Lacarrubba, Vincenzo Maione, Costantino Ricci, Mariano Suppa, Marina Venturini, Elisa Cinotti, Alessandro Di Stefani, Jean Luc Perrot, Pietro Rubegni
{"title":"线场共聚焦光学相干断层扫描用于从临床模拟器鉴别诊断角化病：初步研究。","authors":"Linda Tognetti, Simone Cappilli, Francesca Falcinelli, Simone Soglia, Francesco Lacarrubba, Vincenzo Maione, Costantino Ricci, Mariano Suppa, Marina Venturini, Elisa Cinotti, Alessandro Di Stefani, Jean Luc Perrot, Pietro Rubegni","doi":"10.1093/ced/llae285","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Porokeratosis variants are relatively rare and can be clinically misdiagnosed with several common papulokeratotic mimickers. Line-field confocal optical coherence tomography (LC-OCT) is a new technology able to explore the skin in vivo up to a depth of 500 µm.</p><p><strong>Objectives: </strong>To investigate the role of LC-OCT in the diagnosis of many porokeratosis variants in a preliminary study.</p><p><strong>Method: </strong>In total, 130 LC-OCT images were obtained from 98 patients, 45 affected by a porokeratosis variant (69 images) and 53 with a mimicker condition (61 images).</p><p><strong>Results: </strong>We found almost perfect interobserver agreement for LC-OCT image interpretation and perfect correspondence with the findings from histological slides. In addition, a series of morphological in vivo and three-dimensional features related to the cornoid lamella were detected by LC-OCT that were not visible from the histology.</p><p><strong>Conclusions: </strong>This device can be proposed to assist with rapid bedside noninvasive differentiation of porokeratosis variants from their mimickers, possibly sparing incisional biopsy in patients where the diagnosis is uncertain.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1641-1650"},"PeriodicalIF":3.7000,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Line-field confocal optical coherence tomography for the differential diagnosis of porokeratosis from clinical mimickers: a preliminary study.\",\"authors\":\"Linda Tognetti, Simone Cappilli, Francesca Falcinelli, Simone Soglia, Francesco Lacarrubba, Vincenzo Maione, Costantino Ricci, Mariano Suppa, Marina Venturini, Elisa Cinotti, Alessandro Di Stefani, Jean Luc Perrot, Pietro Rubegni\",\"doi\":\"10.1093/ced/llae285\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Porokeratosis variants are relatively rare and can be clinically misdiagnosed with several common papulokeratotic mimickers. Line-field confocal optical coherence tomography (LC-OCT) is a new technology able to explore the skin in vivo up to a depth of 500 µm.</p><p><strong>Objectives: </strong>To investigate the role of LC-OCT in the diagnosis of many porokeratosis variants in a preliminary study.</p><p><strong>Method: </strong>In total, 130 LC-OCT images were obtained from 98 patients, 45 affected by a porokeratosis variant (69 images) and 53 with a mimicker condition (61 images).</p><p><strong>Results: </strong>We found almost perfect interobserver agreement for LC-OCT image interpretation and perfect correspondence with the findings from histological slides. In addition, a series of morphological in vivo and three-dimensional features related to the cornoid lamella were detected by LC-OCT that were not visible from the histology.</p><p><strong>Conclusions: </strong>This device can be proposed to assist with rapid bedside noninvasive differentiation of porokeratosis variants from their mimickers, possibly sparing incisional biopsy in patients where the diagnosis is uncertain.</p>\",\"PeriodicalId\":10324,\"journal\":{\"name\":\"Clinical and Experimental Dermatology\",\"volume\":\" \",\"pages\":\"1641-1650\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-11-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical and Experimental Dermatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/ced/llae285\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Experimental Dermatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/ced/llae285","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Line-field confocal optical coherence tomography for the differential diagnosis of porokeratosis from clinical mimickers: a preliminary study.
Background: Porokeratosis variants are relatively rare and can be clinically misdiagnosed with several common papulokeratotic mimickers. Line-field confocal optical coherence tomography (LC-OCT) is a new technology able to explore the skin in vivo up to a depth of 500 µm.
Objectives: To investigate the role of LC-OCT in the diagnosis of many porokeratosis variants in a preliminary study.
Method: In total, 130 LC-OCT images were obtained from 98 patients, 45 affected by a porokeratosis variant (69 images) and 53 with a mimicker condition (61 images).
Results: We found almost perfect interobserver agreement for LC-OCT image interpretation and perfect correspondence with the findings from histological slides. In addition, a series of morphological in vivo and three-dimensional features related to the cornoid lamella were detected by LC-OCT that were not visible from the histology.
Conclusions: This device can be proposed to assist with rapid bedside noninvasive differentiation of porokeratosis variants from their mimickers, possibly sparing incisional biopsy in patients where the diagnosis is uncertain.
期刊介绍：
Clinical and Experimental Dermatology (CED) is a unique provider of relevant and educational material for practising clinicians and dermatological researchers. We support continuing professional development (CPD) of dermatology specialists to advance the understanding, management and treatment of skin disease in order to improve patient outcomes.
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