2-取代苯基-3-(5-芳基/杂芳基取代噻唑-2-基)噻唑烷-4-酮衍生物的合成、抗菌评估和硅学研究。

IF 1.6 4区医学 Q4 BIOCHEMICAL RESEARCH METHODS

Assay and drug development technologies Pub Date : 2024-08-01 Epub Date: 2024-07-24 DOI:10.1089/adt.2024.027

Swati Pawar, Ram Karan, Srija Hazarika, Mohan Lal, Ravindra K Rawal, Praveen Kumar Gupta

引用次数: 0

摘要

在 3-(2-氨基噻唑-5-基)-2H-色烯-2-酮/5-(萘-1-基)噻唑-2-胺 5-6 与各种取代醛和巯基乙酸的一锅反应中，我们得到了相应的 2-(4-取代苯基)-3-[5-(2-氧代-2H-色烯-3-基)噻唑-2-基]噻唑烷-4-酮、我们得到了相应的 2-(4-取代苯基)-3-[5-(2-氧代-2H-苯并吡喃-3-基)噻唑-2-基]噻唑烷-4-酮 8(a-h)和 2-(4-取代苯基)-3-[5-(萘-1-基)噻唑-2-基]噻唑烷-4-酮 9(a-h)。评估了所有化合物对铜绿假单胞菌（MTCC-424）、伤寒沙门氏菌（MTCC-531）、金黄色葡萄球菌（MTCC-737）和白色念珠菌（MTCC-227）的抗菌活性。分子对接进一步证实了这些发现，结果表明化合物 8d 和 9d 对所有测试的病原体都有很好的抗菌作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthesis, Antimicrobial Evaluation, and In Silico Studies of 2-Substituted-Phenyl-3-(5-Aryl/Heteroaryl Substituted Thiazol-2-yl) Thiazolidin-4-One Derivatives.

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来源期刊

Assay and drug development technologies 医学-生化研究方法

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： ASSAY and Drug Development Technologies provides access to novel techniques and robust tools that enable critical advances in early-stage screening. This research published in the Journal leads to important therapeutics and platforms for drug discovery and development. This reputable peer-reviewed journal features original papers application-oriented technology reviews, topical issues on novel and burgeoning areas of research, and reports in methodology and technology application. ASSAY and Drug Development Technologies coverage includes: -Assay design, target development, and high-throughput technologies- Hit to Lead optimization and medicinal chemistry through preclinical candidate selection- Lab automation, sample management, bioinformatics, data mining, virtual screening, and data analysis- Approaches to assays configured for gene families, inherited, and infectious diseases- Assays and strategies for adapting model organisms to drug discovery- The use of stem cells as models of disease- Translation of phenotypic outputs to target identification- Exploration and mechanistic studies of the technical basis for assay and screening artifacts