胃蛋白酶原 I、胃蛋白酶原 II、胃泌素-17 和幽门螺旋杆菌血清学生物标志物在胃癌前病变诊断中的应用。

IF 3 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Archives of Medical Science Pub Date : 2024-06-28 eCollection Date: 2024-01-01 DOI:10.5114/aoms/189971

Josefina Yoaly Sánchez-López, Luis Carlos Díaz-Herrera, Lourdes Del Carmen Rizo-de la Torre

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引用次数: 0

摘要

简介：萎缩性胃炎和肠化生是胃癌的前兆病变：萎缩性胃炎和肠化生是胃癌的前驱病变。本研究旨在确定胃蛋白酶原 I (PgI)、胃蛋白酶原 II (PgII)、胃泌素-17 和幽门螺杆菌抗体等生物标志物在识别前驱病变中的作用：我们对 129 名有胃部症状的患者进行了研究。方法：我们对 129 名有胃部症状的患者进行了研究，通过 ELISA 技术使用 GastroPanel 对生物标志物状态进行了测定：结果：14%的受试者通过生物标志物检测到胃萎缩，49.6%的受试者幽门螺杆菌抗体呈阳性。PgI/PgII比值小于3是我们人群中前驱病变的重要风险生物标志物（OR = 9.171，95% CI：1.723-48.799，p = 0.009）；然而，生物标志物与组织病理学研究的准确性较低：在墨西哥西部人群中，前驱病变（AG、IM）常见于患有消化不良的成年人（45%），但在儿童中并不常见（8%）。41.3%的成人和16.0%的儿童检测出幽门螺杆菌感染。在所研究的生物标志物中，PgI/PgII 比率小于 3 是我们人群中出现 AG 或 IM 等前驱病变的重要风险因素，OR 值为 9.171（95% CI：1.723-48.799，P = 0.009）。

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Pepsinogen I, pepsinogen II, gastrin-17, and Helicobacter pylori serological biomarkers in the diagnosis of precursor lesions of gastric cancer.

Introduction: Atrophic gastritis and intestinal metaplasia are precursor lesions of gastric cancer. The aim of this study was to determine the usefulness of the biomarkers pepsinogen I(PgI), pepsinogen II (PgII), gastrin-17, and H. pylori antibodies in the identification of precursor lesions.

Methods: We studied 129 patients with gastric symptoms. The biomarker status was determined using GastroPanel by means of the ELISA-technique.

Results: Biomarkers detected atrophy in 14% of the subjects, and 49.6% had positive antibodies for H. pylori. A PgI/PgII ratio < 3 was an important risk biomarker for precursor lesions in our population (OR = 9.171, 95% CI: 1.723-48.799, p = 0.009); however, biomarkers showed low accuracy with histopathological study.

Conclusions: In the Western Mexican population, precursor lesions (AG, IM) are common in adults (45%) with dyspepsia but infrequent in children (8%). H. pylori infection was detected in 41.3% of adults and 16.0% of children. Of the studied biomarkers, a PgI/PgII ratio < 3 was an important risk factor for precursor lesions such as AG or IM in our population, with an OR of 9.171 (95% CI: 1.723-48.799, p = 0.009).

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来源期刊

Archives of Medical Science 医学-医学：内科

CiteScore

4.90

自引率

7.90%

发文量

139

审稿时长

1.7 months

期刊介绍： Archives of Medical Science (AMS) publishes high quality original articles and reviews of recognized scientists that deal with all scientific medicine. AMS opens the possibilities for young, capable scientists. The journal would like to give them a chance to have a publication following matter-of-fact, professional review by outstanding, famous medical scientists. Thanks to that they will have an opportunity to present their study results and/or receive useful advice about the mistakes they have made so far. The second equally important aim is a presentation of review manuscripts of recognized scientists about the educational capacity, in order that young scientists, often at the beginning of their scientific carrier, could constantly deepen their medical knowledge and be up-to-date with current guidelines and trends in world-wide medicine. The fact that our educational articles are written by world-famous scientists determines their innovation and the highest quality.