Katarina Banjac, Milan Obradovic, Sonja Zafirovic, Esma R Isenovic
{"title":"胰岛素样生长因子-1通过减少AMPK/FOXO1信号传导和Na+/K+-ATPase-Beclin-1相互作用减少心脏自律性。","authors":"Katarina Banjac, Milan Obradovic, Sonja Zafirovic, Esma R Isenovic","doi":"10.5114/aoms/177618","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Insulin-like growth factor-1 (IGF-1) promotes survival and inhibits cardiac autophagy disruption.</p><p><strong>Methods: </strong>Male Wistar rats were treated with IGF-1 (50 µg/kg), and 24 h after injection hearts were excised. The level of interaction between Beclin-1 and the α<sub>1</sub> subunit of sodium/potassium-adenosine triphosphates (Na<sup>+</sup>/K<sup>+</sup>-ATPase), and phosphorylated forms of IGF-1 receptor/insulin receptor (IGF-1R/IR), forkhead box protein O1 (FOXO1) and AMP-activated protein kinase (AMPK) were measured.</p><p><strong>Results: </strong>The results indicate that IGF-1 decreased Beclin-1's association with Na<sup>+</sup>/K<sup>+</sup>-ATPase (<i>p</i> < 0.05), increased IGF-1R/IR and FOXO1 phosphorylation (<i>p</i> < 0.05), and decreased AMPK phosphorylation (<i>p</i> < 0.01) in rats' hearts.</p><p><strong>Conclusions: </strong>The new IGF-1 therapy may control autosis and minimize cardiomyocyte mortality.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 3","pages":"1011-1015"},"PeriodicalIF":3.0000,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264057/pdf/","citationCount":"0","resultStr":"{\"title\":\"Insulin-like growth factor-1 reduces cardiac autosis through decreasing AMPK/FOXO1 signaling and Na<sup>+</sup>/K<sup>+</sup>-ATPase-Beclin-1 interaction.\",\"authors\":\"Katarina Banjac, Milan Obradovic, Sonja Zafirovic, Esma R Isenovic\",\"doi\":\"10.5114/aoms/177618\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Insulin-like growth factor-1 (IGF-1) promotes survival and inhibits cardiac autophagy disruption.</p><p><strong>Methods: </strong>Male Wistar rats were treated with IGF-1 (50 µg/kg), and 24 h after injection hearts were excised. The level of interaction between Beclin-1 and the α<sub>1</sub> subunit of sodium/potassium-adenosine triphosphates (Na<sup>+</sup>/K<sup>+</sup>-ATPase), and phosphorylated forms of IGF-1 receptor/insulin receptor (IGF-1R/IR), forkhead box protein O1 (FOXO1) and AMP-activated protein kinase (AMPK) were measured.</p><p><strong>Results: </strong>The results indicate that IGF-1 decreased Beclin-1's association with Na<sup>+</sup>/K<sup>+</sup>-ATPase (<i>p</i> < 0.05), increased IGF-1R/IR and FOXO1 phosphorylation (<i>p</i> < 0.05), and decreased AMPK phosphorylation (<i>p</i> < 0.01) in rats' hearts.</p><p><strong>Conclusions: </strong>The new IGF-1 therapy may control autosis and minimize cardiomyocyte mortality.</p>\",\"PeriodicalId\":8278,\"journal\":{\"name\":\"Archives of Medical Science\",\"volume\":\"20 3\",\"pages\":\"1011-1015\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2024-01-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264057/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of Medical Science\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5114/aoms/177618\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Medical Science","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5114/aoms/177618","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Methods: Male Wistar rats were treated with IGF-1 (50 µg/kg), and 24 h after injection hearts were excised. The level of interaction between Beclin-1 and the α1 subunit of sodium/potassium-adenosine triphosphates (Na+/K+-ATPase), and phosphorylated forms of IGF-1 receptor/insulin receptor (IGF-1R/IR), forkhead box protein O1 (FOXO1) and AMP-activated protein kinase (AMPK) were measured.
Results: The results indicate that IGF-1 decreased Beclin-1's association with Na+/K+-ATPase (p < 0.05), increased IGF-1R/IR and FOXO1 phosphorylation (p < 0.05), and decreased AMPK phosphorylation (p < 0.01) in rats' hearts.
Conclusions: The new IGF-1 therapy may control autosis and minimize cardiomyocyte mortality.
期刊介绍：
Archives of Medical Science (AMS) publishes high quality original articles and reviews of recognized scientists that deal with all scientific medicine. AMS opens the possibilities for young, capable scientists. The journal would like to give them a chance to have a publication following matter-of-fact, professional review by outstanding, famous medical scientists. Thanks to that they will have an opportunity to present their study results and/or receive useful advice about the mistakes they have made so far.
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