利奈唑胺治疗结核性脑膜炎的疗效：一项荟萃分析。

IF 3 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Archives of Medical Science Pub Date : 2024-06-29 eCollection Date: 2024-01-01 DOI:10.5114/aoms/189905

Xiaoshu Liu, Daoyan Tang, Min Qi, Jian-Qing He

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引用次数: 0

摘要

简介结核性脑膜炎（TBM）是一种严重的肺外结核病，致死率很高。这项荟萃分析旨在评估利奈唑胺对结核性脑膜炎治疗效果的影响：我们在多个数据库中检索了截至 2024 年 5 月 18 日发表的比较利奈唑胺对 TBM 影响的研究。使用Review Manager 5.4进行了元分析：我们的研究结果表明，利奈唑胺可降低TBM患者的治疗失败风险（RR = 0.42 (0.20, 0.89), p = 0.02），改善体温恢复（RR = 1.56 (1.21, 2.02), p < 0.001）：分析表明，利奈唑胺治疗与治疗效果改善之间存在正相关，且无重大不良反应报告。

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Efficacy of linezolid in the treatment of tuberculous meningitis: a meta-analysis.

Introduction: Tuberculous meningitis (TBM) is a severe extra-pulmonary tuberculosis with high fatality. This meta-analysis aimed to assess the impact of linezolid on TBM treatment outcomes.

Methods: We searched multiple databases for studies published up to May 18, 2024 comparing the effects of linezolid on TBM. Meta-analysis was conducted using Review Manager 5.4.

Results: Our findings indicated that linezolid may reduce treatment failure risk (RR = 0.42 (0.20, 0.89), p = 0.02) and improve temperature recovery (RR = 1.56 (1.21, 2.02), p < 0.001) in TBM patients.

Conclusions: The analysis suggests a positive association between linezolid treatment and therapeutic improvements, with no significant adverse reactions reported.

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来源期刊

Archives of Medical Science 医学-医学：内科

CiteScore

4.90

自引率

7.90%

发文量

139

审稿时长

1.7 months

期刊介绍： Archives of Medical Science (AMS) publishes high quality original articles and reviews of recognized scientists that deal with all scientific medicine. AMS opens the possibilities for young, capable scientists. The journal would like to give them a chance to have a publication following matter-of-fact, professional review by outstanding, famous medical scientists. Thanks to that they will have an opportunity to present their study results and/or receive useful advice about the mistakes they have made so far. The second equally important aim is a presentation of review manuscripts of recognized scientists about the educational capacity, in order that young scientists, often at the beginning of their scientific carrier, could constantly deepen their medical knowledge and be up-to-date with current guidelines and trends in world-wide medicine. The fact that our educational articles are written by world-famous scientists determines their innovation and the highest quality.