酶学：了解细胞中的酶相互作用和表观遗传。

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2024-10-01 DOI:10.1016/j.tibs.2024.07.002

Andrew Savinov

引用次数: 0

摘要

Nguyen 等人的最新研究揭示了在自然细胞背景下，对二氢叶酸还原酶和胸腺嘧啶合成酶这两种酶之间的表观相互作用的大规模并行测量。三种 TYMS 背景中近 3000 个 DHFR 突变揭示了复杂的相互作用网络。作者用一个简单的模型捕捉到了这种复杂性的大部分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Enzoology: understanding enzyme interactions and epistasis in the cell

Recent work from Nguyen et al. unveils massively parallel measurements of epistatic interactions between two enzymes, dihydrofolate reductase and thymidylate synthase, in their natural cellular context. Almost 3000 mutations of DHFR in three TYMS backgrounds reveal a complex interaction network. The authors capture much of this complexity using a simple model.

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.