{"title":"关注表达:HOXD-AS1/miR-130a 海绵通过靶向 E2F8 调节胶质瘤的发展。","authors":"","doi":"10.1002/ijc.35119","DOIUrl":null,"url":null,"abstract":"<p>\n <span>Chen, Y.</span>, <span>Zhao, F.</span>, <span>Cui, D.</span>, <span>Jiang, R.</span>, <span>Chen, J.</span>, <span>Huang, Q.</span> and <span>Shi, J.</span> (<span>2018</span>), <span>HOXD-AS1/miR-130a sponge regulates glioma development by targeting E2F8</span>. <i>Int. J. Cancer</i>, <span>142</span>: <span>2313</span>–<span>2322</span>. https://doi.org/10.1002/ijc.31262.</p><p>This Expression of Concern is for the above article, published online on 17 January 2018 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Christoph Plass, the Union for International Cancer Control and John Wiley & Sons, Ltd.</p><p>The Expression of Concern has been agreed due to concerns raised by third parties regarding the data presented in Figure 5b and 5c. Specifically, the si-NC panel in Figure 5b (cell migration) appears to overlap with the si-NC panel in Figure 5c (cell invasion) when rotated. The authors acknowledged that the image for si-NC in Figure 5c was mislabeled and that they were no longer able to locate the original image underlying si-NC in Figure 5c due to problems with data storage. Additionally, it has come to the attention of the journal that in Figure 4c the blots displaying the loading control β-actin do not originate from the same blots where E2F7 and E2F8 were detected. The authors have indicated that E2F7, E2F8, and β-actin expression levels were detected on different membranes. However, they assure that the same experimental protocol was rigorously followed. The journal has issued this Expression of Concern to inform and alert readers.</p>","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":null,"pages":null},"PeriodicalIF":5.7000,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijc.35119","citationCount":"0","resultStr":"{\"title\":\"Expression of Concern: HOXD-AS1/miR-130a sponge regulates glioma development by targeting E2F8\",\"authors\":\"\",\"doi\":\"10.1002/ijc.35119\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>\\n <span>Chen, Y.</span>, <span>Zhao, F.</span>, <span>Cui, D.</span>, <span>Jiang, R.</span>, <span>Chen, J.</span>, <span>Huang, Q.</span> and <span>Shi, J.</span> (<span>2018</span>), <span>HOXD-AS1/miR-130a sponge regulates glioma development by targeting E2F8</span>. <i>Int. J. Cancer</i>, <span>142</span>: <span>2313</span>–<span>2322</span>. https://doi.org/10.1002/ijc.31262.</p><p>This Expression of Concern is for the above article, published online on 17 January 2018 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Christoph Plass, the Union for International Cancer Control and John Wiley & Sons, Ltd.</p><p>The Expression of Concern has been agreed due to concerns raised by third parties regarding the data presented in Figure 5b and 5c. Specifically, the si-NC panel in Figure 5b (cell migration) appears to overlap with the si-NC panel in Figure 5c (cell invasion) when rotated. The authors acknowledged that the image for si-NC in Figure 5c was mislabeled and that they were no longer able to locate the original image underlying si-NC in Figure 5c due to problems with data storage. Additionally, it has come to the attention of the journal that in Figure 4c the blots displaying the loading control β-actin do not originate from the same blots where E2F7 and E2F8 were detected. The authors have indicated that E2F7, E2F8, and β-actin expression levels were detected on different membranes. However, they assure that the same experimental protocol was rigorously followed. 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引用次数: 0
摘要
Chen, Y., Zhao, F., Cui, D., Jiang, R., Chen, J., Huang, Q. and Shi, J. (2018), HOXD-AS1/miR-130a sponge regulates glioma development by targeting E2F8.Int.J. Cancer, 142: 2313-2322. https://doi.org/10.1002/ijc.31262.This 《关注声明》是针对 2018 年 1 月 17 日在线发表在 Wiley Online Library(wileyonlinelibrary.com)上的上述文章,由期刊主编克里斯托夫-普拉斯(Christoph Plass)、国际癌症控制联盟(Union for International Cancer Control)和 John Wiley & Sons, Ltd.协商发布。《关注声明》的发布是由于第三方对图 5b 和 5c 中的数据提出了担忧。具体而言,图 5b 中的 si-NC 面板(细胞迁移)旋转后似乎与图 5c(细胞侵袭)中的 si-NC 面板重叠。作者承认,图 5c 中的 si-NC 图像标注有误,而且由于数据存储问题,他们已无法找到图 5c 中 si-NC 底部的原始图像。此外,本刊还注意到,图 4c 中显示负载对照 β-actin 的印迹并非来自检测到 E2F7 和 E2F8 的同一印迹。作者指出,在不同的膜上检测到了 E2F7、E2F8 和 β-肌动蛋白的表达水平。不过,他们保证严格遵循了相同的实验方案。本刊特发布此《关注声明》,以告知和提醒读者。
Expression of Concern: HOXD-AS1/miR-130a sponge regulates glioma development by targeting E2F8
Chen, Y., Zhao, F., Cui, D., Jiang, R., Chen, J., Huang, Q. and Shi, J. (2018), HOXD-AS1/miR-130a sponge regulates glioma development by targeting E2F8. Int. J. Cancer, 142: 2313–2322. https://doi.org/10.1002/ijc.31262.
This Expression of Concern is for the above article, published online on 17 January 2018 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Christoph Plass, the Union for International Cancer Control and John Wiley & Sons, Ltd.
The Expression of Concern has been agreed due to concerns raised by third parties regarding the data presented in Figure 5b and 5c. Specifically, the si-NC panel in Figure 5b (cell migration) appears to overlap with the si-NC panel in Figure 5c (cell invasion) when rotated. The authors acknowledged that the image for si-NC in Figure 5c was mislabeled and that they were no longer able to locate the original image underlying si-NC in Figure 5c due to problems with data storage. Additionally, it has come to the attention of the journal that in Figure 4c the blots displaying the loading control β-actin do not originate from the same blots where E2F7 and E2F8 were detected. The authors have indicated that E2F7, E2F8, and β-actin expression levels were detected on different membranes. However, they assure that the same experimental protocol was rigorously followed. The journal has issued this Expression of Concern to inform and alert readers.
期刊介绍:
The International Journal of Cancer (IJC) is the official journal of the Union for International Cancer Control—UICC; it appears twice a month. IJC invites submission of manuscripts under a broad scope of topics relevant to experimental and clinical cancer research and publishes original Research Articles and Short Reports under the following categories:
-Cancer Epidemiology-
Cancer Genetics and Epigenetics-
Infectious Causes of Cancer-
Innovative Tools and Methods-
Molecular Cancer Biology-
Tumor Immunology and Microenvironment-
Tumor Markers and Signatures-
Cancer Therapy and Prevention