通过超激活树突状细胞 "增强 "老年小鼠的肿瘤免疫力

IF 45.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Pub Date : 2024-07-25 DOI:10.1016/j.cell.2024.06.025

引用次数: 0

摘要

免疫衰老给老年人的肿瘤免疫疗法带来了巨大挑战。在本期《细胞》杂志上，Zhivaki 等人阐明了树突状细胞在特定佐剂的 "过度激活 "下，以一种依赖于 NLRP3 炎症小体的方式引发 TH1 偏向的 CD4+ T 细胞反应，从而消除老年小鼠体内的肿瘤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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“Boosting” tumor immunity in elderly mice by hyperactivating dendritic cells

Immunosenescence poses a significant challenge to tumor immunotherapy in elderly individuals. In this issue of Cell, Zhivaki et al. elucidate that dendritic cells “hyperactivated” by specific adjuvants elicit T_H1-skewed CD4⁺ T cell responses in a manner contingent on the NLRP3 inflammasome, which can eliminate tumors in aged mice.

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来源期刊

Cell 生物-生化与分子生物学

CiteScore

110.00

自引率

0.80%

发文量

396

审稿时长

2 months

期刊介绍： Cells is an international, peer-reviewed, open access journal that focuses on cell biology, molecular biology, and biophysics. It is affiliated with several societies, including the Spanish Society for Biochemistry and Molecular Biology (SEBBM), Nordic Autophagy Society (NAS), Spanish Society of Hematology and Hemotherapy (SEHH), and Society for Regenerative Medicine (Russian Federation) (RPO). The journal publishes research findings of significant importance in various areas of experimental biology, such as cell biology, molecular biology, neuroscience, immunology, virology, microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics. The primary criterion for considering papers is whether the results contribute to significant conceptual advances or raise thought-provoking questions and hypotheses related to interesting and important biological inquiries. In addition to primary research articles presented in four formats, Cells also features review and opinion articles in its "leading edge" section, discussing recent research advancements and topics of interest to its wide readership.