Prephenate decarboxylase:通向不寻常天然产物的一个尚未探索的分支点

IF 6.6 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Mostafa Hagar , Raymond J. Andersen , Katherine S. Ryan
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引用次数: 0

摘要

预铼酸脱羧酶是一个小的酶家族,它启动了莽草酸途径的专门分化,在该途径中,预铼酸(2)被脱羧而不芳香化。除了进行具有挑战性的化学转化外,预苯甲酸脱羧酶还参与生产罕见的特殊代谢物,有时直接构建具有生物活性的弹头。由前铼酸盐脱羧酶衍生出的天然产物的许多生物合成步骤仍然难以捉摸。在此,我们回顾了迄今为止的预苯甲酸脱羧酶研究,并重点介绍了可能从涉及预苯甲酸脱羧酶的生物合成途径中提取的天然产物。我们还重点介绍了在这些天然产物的结构阐释过程中通常会遇到的挑战。预铼酸脱羧酶是进入未被充分研究的生物合成途径的一个通道,它为发现新型和具有生物活性的天然产物以及新的生物合成酶提供了巨大的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Prephenate decarboxylase: An unexplored branchpoint to unusual natural products

Prephenate decarboxylase: An unexplored branchpoint to unusual natural products

Prephenate decarboxylase: An unexplored branchpoint to unusual natural products

Prephenate decarboxylases are a small family of enzymes which initiate a specialized divergence from the shikimate pathway, where prephenate (2) is decarboxylated without aromatization. In addition to effecting a challenging chemical transformation, prephenate decarboxylases have been implicated in the production of rare specialized metabolites, sometimes directly constructing bioactive warheads. Many of the biosynthetic steps to natural products derived from prephenate decarboxylases remain elusive. Here, we review prephenate decarboxylase research thus far and highlight natural products that may be derived from biosynthetic pathways involving prephenate decarboxylases. We also highlight commonly encountered challenges in the structure elucidation of these natural products. Prephenate decarboxylases are a gateway into understudied biosynthetic pathways which present a high potential for the discovery of novel and bioactive natural products, as well as new biosynthetic enzymes.

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来源期刊
Cell Chemical Biology
Cell Chemical Biology Biochemistry, Genetics and Molecular Biology-Molecular Medicine
CiteScore
14.70
自引率
2.30%
发文量
143
期刊介绍: Cell Chemical Biology, a Cell Press journal established in 1994 as Chemistry & Biology, focuses on publishing crucial advances in chemical biology research with broad appeal to our diverse community, spanning basic scientists to clinicians. Pioneering investigations at the chemistry-biology interface, the journal fosters collaboration between these disciplines. We encourage submissions providing significant conceptual advancements of broad interest across chemical, biological, clinical, and related fields. Particularly sought are articles utilizing chemical tools to perturb, visualize, and measure biological systems, offering unique insights into molecular mechanisms, disease biology, and therapeutics.
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