β-二羰基化合物的α-羟基化研究进展

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2024-09-17 DOI:10.1002/adsc.202400627

Shuai Peng , Fangyao Su , Shuting Yin , Baoguo Sun , Hongyu Tian , Sen Liang

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引用次数: 0

摘要

在许多具有生物活性的化合物中，α-羟基-β-二羰基基团是必不可少的，这引发了人们对其合成的极大兴趣。本综述全面研究了 α- 羟基-β-二羰基化合物的合成进展，根据所使用的氧化剂类型对方法进行了系统分类，并重点介绍了不对称 α- 羟基合成的进展。报告评估了每种方法的底物范围、优缺点，总结了可能涉及的中间产物和反应机制类型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Advances in α‐Hydroxylation of β‐Dicarbonyl Compounds

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Advances in α‐Hydroxylation of β‐Dicarbonyl Compounds

The α‐hydroxy‐β‐dicarbonyl motif is essential in many biologically active compounds, sparking significant interest in their synthesis. This review comprehensively examines the advancements in the α‐hydroxylation of β‐dicarbonyl compounds, systematically categorizing the methods based on the types of oxidants employed and highlighting advances in asymmetric α‐hydroxylation. It evaluates the substrate scope, advantages, and disadvantages of each approach, summarizing the possible intermediates involved and the types of reaction mechanisms.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.