盐酸胍（GuHCl）催化的微波介导的嘧啶并[1,2-a]苯并咪唑与芳基醛和芳基甲基酮的无溶剂和无金属合成反应

IF 9.3 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Green Chemistry Pub Date : 2024-08-12 DOI:10.1039/d4gc01363h

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引用次数: 0

摘要

本研究开发了一种新颖的微波介导合成方法，利用简单且具有成本效益的起始材料，快速、高产且环保地生产出嘧啶并[1,2-a]苯并咪唑。绿色有机催化剂盐酸胍促进了该反应的进行。该方案提供了一种无金属有机催化技术，可获得高荧光嘧啶并[1,2-a]苯并咪唑衍生物库。这种合成方法的主要特点包括与官能团的广泛兼容性、操作简便性和可扩展性，使其成为一种具有多种应用前景的技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Guanidine hydrochloride (GuHCl)-catalysed microwave-mediated solvent- and metal-free synthesis of pyrimido[1,2-a]benzimidazole from aryl aldehyde and aryl methyl ketone†

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Guanidine hydrochloride (GuHCl)-catalysed microwave-mediated solvent- and metal-free synthesis of pyrimido[1,2-a]benzimidazole from aryl aldehyde and aryl methyl ketone†

A novel microwave-mediated synthesis method was developed for the rapid and eco-friendly production of pyrimido[1,2-a]benzimidazole in high yields utilizing simple and cost-effective starting materials. This reaction was facilitated by the green organocatalyst guanidine hydrochloride. This protocol offers a metal-free and organocatalysed technique to afford a library of highly fluorescent pyrimido[1,2-a]benzimidazole derivatives. Key features of this synthetic method include its broad compatibility with functional groups, operational simplicity, and scalability, making it a promising technique for various applications.

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来源期刊

Green Chemistry 化学-化学综合

CiteScore

16.10

自引率

7.10%

发文量

677

审稿时长

1.4 months

期刊介绍： Green Chemistry is a journal that provides a unique forum for the publication of innovative research on the development of alternative green and sustainable technologies. The scope of Green Chemistry is based on the definition proposed by Anastas and Warner (Green Chemistry: Theory and Practice, P T Anastas and J C Warner, Oxford University Press, Oxford, 1998), which defines green chemistry as the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green Chemistry aims to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. The journal welcomes submissions on all aspects of research relating to this endeavor and publishes original and significant cutting-edge research that is likely to be of wide general appeal. For a work to be published, it must present a significant advance in green chemistry, including a comparison with existing methods and a demonstration of advantages over those methods.