微生物简介：噬菌体ϕ6：分段 RNA 病毒的模型和病毒 "性 "的进化后果。

IF 2.6 4区生物学 Q3 MICROBIOLOGY

Microbiology-Sgm Pub Date : 2024-07-01 DOI:10.1099/mic.0.001467

Paul E Turner, Lin Chao

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引用次数: 0

摘要

噬菌体ϕ6是一种具有脂质包膜的分段dsRNA病毒，这在细菌病毒中并不常见，但在真核病毒中却很常见。这种独特性使ϕ6 及其假单胞菌宿主成为细菌和真核病毒中 RNA 遗传学、突变、复制、包装和重配的分子模型。然而，ϕ6的另一个独特之处在于它的高突变率，即它可以作为一个实验系统来研究一些关键问题，如性的进化（片段重配）、宿主与病原体的相互作用、突变负荷、适应率、遗传和表型复杂性以及博弈论。

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Microbe Profile: Bacteriophage ϕ6: a model for segmented RNA viruses and the evolutionary consequences of viral 'sex'.

Bacteriophage ϕ6 is a segmented dsRNA virus with a lipid envelope, which are unusual traits in bacterial viruses but common in eukaryotic viruses. This uniqueness allowed ϕ6 and its Pseudomonad hosts to serve as a molecular model for RNA genetics, mutation, replication, packaging, and reassortment in both bacterial and eukaryotic viruses. However, an additional uniqueness of ϕ6, created by its high mutation rate, was its use as an experimental system to study key questions such as the evolution of sex (segment reassortment), host-pathogen interactions, mutational load, rates of adaptation, genetic and phenotypic complexity, and game theory.

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来源期刊

Microbiology-Sgm 生物-微生物学

CiteScore

4.60

自引率

7.10%

发文量

132

审稿时长

3.0 months

期刊介绍： We publish high-quality original research on bacteria, fungi, protists, archaea, algae, parasites and other microscopic life forms. Topics include but are not limited to: Antimicrobials and antimicrobial resistance Bacteriology and parasitology Biochemistry and biophysics Biofilms and biological systems Biotechnology and bioremediation Cell biology and signalling Chemical biology Cross-disciplinary work Ecology and environmental microbiology Food microbiology Genetics Host–microbe interactions Microbial methods and techniques Microscopy and imaging Omics, including genomics, proteomics and metabolomics Physiology and metabolism Systems biology and synthetic biology The microbiome.