长期补骨脂素加紫外线 A 和小剂量干扰素-A 联合疗法对真菌病的疗效:文献综述。

IF 2.5 4区 医学 Q2 DERMATOLOGY
Hatice Şanlı, İncilay Kalay Yıldızhan, Kaan Gündüz, Bengü Nisa Akay
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引用次数: 0

摘要

背景/目的:干扰素(IFN)-a通常与补骨脂素加紫外线A(PUVA)联合用于早期或晚期皮肤靶向疗法难治性真菌病(MF)患者。主要目的是评估PUVA和小剂量IFN-α-2a联合疗法对早期和晚期MF患者的疗效:方法:回顾性研究了68例接受PUVA每周两次或三次和INF-a每周三次、每次3 MU联合治疗至少3个月的患者。治疗反应被评估为完全缓解(CR)、部分缓解、病情稳定或进展:开始治疗时,大多数患者(66.2%)处于疾病早期。在27.9%的病例中,这是确诊骨髓纤维化后的首次治疗。联合疗法的中位持续时间为11个月。45.6%的患者获得了完全缓解,总体反应率为60.3%。平均应答持续时间为 5 个月。完全缓解率在统计学上明显高于早期患者(P .05):研究结果表明,PUVA + 低剂量 INF-a 联合疗法对早期患者的疗效优于晚期患者。此外,获得 CR 的患者在停止治疗后复发率较高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The efficacy of long-term psoralen plus ultraviolet A and low-dose interferon-a combination therapy in mycosis fungoides: A literature review.

Background/purpose: Interferon (IFN)-a is often used in combination with psoralen plus ultraviolet A (PUVA) in patients with mycosis fungoides (MF) refractory to skin-targeted therapies in early or advanced stages. The main objective is to evaluate the effectiveness of combined PUVA and low-dose IFN-α-2a therapy in patients with early- and advanced-stage MF.

Methods: Sixty-eight patients who received a combination of PUVA twice or thrice a week and INF-a 3 MU thrice a week for at least 3 months were reviewed retrospectively. The treatment response was evaluated as complete remission (CR), partial remission, stable disease, or progression.

Results: At the initiation, the majority of patients (66.2%) had early-stage disease. In 27.9% of cases, this was the initial treatment administered following the diagnosis of MF. The median duration of combination therapy was 11 months. Complete remission was achieved in 45.6% of the patients with an overall response rate of 60.3%. The mean duration of response was 5 months. Complete remission was statistically significantly higher in early-stage patients (p < .05). No statistically significant correlation was observed between CR and gender, histopathological features, or laboratory parameters. In patients with CR, 80% experienced relapse, significantly higher in early-stage patients (p < .05). However, there was no significant difference in disease-free survival between early and advanced stages (p > .05).

Conclusions: The study results indicated that PUVA + low-dose INF-a combination therapy was more effective in the early stage than in the advanced stage. Additionally, there was a high relapse rate after the cessation of treatment in patients who achieved CR.

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来源期刊
CiteScore
4.40
自引率
7.70%
发文量
85
审稿时长
6-12 weeks
期刊介绍: The journal is a forum for new information about the direct and distant effects of electromagnetic radiation (ultraviolet, visible and infrared) mediated through skin. The divisions of the editorial board reflect areas of specific interest: aging, carcinogenesis, immunology, instrumentation and optics, lasers, photodynamic therapy, photosensitivity, pigmentation and therapy. Photodermatology, Photoimmunology & Photomedicine includes original articles, reviews, communications and editorials. Original articles may include the investigation of experimental or pathological processes in humans or animals in vivo or the investigation of radiation effects in cells or tissues in vitro. Methodology need have no limitation; rather, it should be appropriate to the question addressed.
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