Paige A Bommarito, Sophia M Blaauwendraad, Danielle R Stevens, Michiel A van den Dries, Suzanne Spaan, Anjoeka Pronk, Henning Tiemeier, Romy Gaillard, Leonardo Trasande, Vincent V W Jaddoe, Kelly K Ferguson
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引用次数: 0
摘要
导言:产前接触非持久性化学物质(包括有机磷农药、邻苯二甲酸盐和双酚)与胎儿和儿童的生长变化有关。很少有研究利用纵向生长轨迹或考虑化学混合物的暴露来研究这些关联:方法:在 R 世代研究的 777 名参与者中,我们使用生长混合物模型,利用从产前到 13 岁期间收集的体重和身高测量数据来确定体重和体重指数(BMI)轨迹。我们在孕期的三个时间点测量了母体尿液中有机磷农药、邻苯二甲酸盐和双酚的暴露生物标志物。我们采用多项式逻辑回归来估计平均暴露生物标记物浓度与生长轨迹之间的关联。我们使用量子 g 计算方法来估计与生长轨迹的联合关联:结果:邻苯二甲酸(OR:1.4,95% CI:1.01,1.9)和双酚 A(BPA;OR:1.5,95% CI:1.0,2.2)与出生前体重较小、儿童期体重较大的生长轨迹相关,而参考轨迹为出生前体重较大、儿童期体重一般。有机磷农药的生物标志物(单独或共同)与以平均产前体重和较低儿童体重为特征的较低生长轨迹几率相关:结论:接触邻苯二甲酸盐和双酚 A 与以较低的产前体重和较高的儿童期体重为特征的体重轨迹呈正相关,而接触有机磷农药与平均的产前体重和较低的儿童期体重轨迹呈负相关。这项研究与非持久性化学物质暴露会扰乱从产前到儿童期的生长轨迹这一假设是一致的。
Prenatal Exposure to Nonpersistent Chemicals and Fetal-to-childhood Growth Trajectories.
Introduction: Prenatal exposure to nonpersistent chemicals, including organophosphate pesticides, phthalates, and bisphenols, is associated with altered fetal and childhood growth. Few studies have examined these associations using longitudinal growth trajectories or considering exposure to chemical mixtures.
Methods: Among 777 participants from the Generation R Study, we used growth mixture models to identify weight and body mass index trajectories using weight and height measures collected from the prenatal period to age 13. We measured exposure biomarkers for organophosphate pesticides, phthalates, and bisphenols in maternal urine at three timepoints during pregnancy. Multinomial logistic regression was used to estimate associations between averaged exposure biomarker concentrations and growth trajectories. We used quantile g-computation to estimate joint associations with growth trajectories.
Results: Phthalic acid (OR = 1.4; 95% CI = 1.01, 1.9) and bisphenol A (OR = 1.5; 95% CI = 1.0, 2.2) were associated with higher odds of a growth trajectory characterized by smaller prenatal and larger childhood weight relative to a referent trajectory of larger prenatal and average childhood weight. Biomarkers of organophosphate pesticides, individually and jointly, were associated with lower odds of a growth trajectory characterized by average prenatal and lower childhood weight.
Conclusions: Exposure to phthalates and bisphenol A was positively associated with a weight trajectory characterized by lower prenatal and higher childhood weight, while exposure to organophosphate pesticides was negatively associated with a trajectory of average prenatal and lower childhood weight. This study is consistent with the hypothesis that nonpersistent chemical exposures disrupt growth trajectories from the prenatal period through childhood.
期刊介绍:
Epidemiology publishes original research from all fields of epidemiology. The journal also welcomes review articles and meta-analyses, novel hypotheses, descriptions and applications of new methods, and discussions of research theory or public health policy. We give special consideration to papers from developing countries.