Seulkee Heo, Longxiang Li, Ji-Young Son, Petros Koutrakis, Michelle L Bell
{"title":"美国康涅狄格州妊娠期住宅氡暴露与足月低出生体重之间的关系。","authors":"Seulkee Heo, Longxiang Li, Ji-Young Son, Petros Koutrakis, Michelle L Bell","doi":"10.1097/EDE.0000000000001771","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Studies suggest biologic mechanisms for gestational exposure to radiation and impaired fetal development. We explored associations between gestational radon exposure and term low birthweight, for which evidence is limited.</p><p><strong>Methods: </strong>We examined data for 68,159 singleton full-term births in Connecticut, United States, 2016-2018. Using a radon spatiotemporal model, we estimated ZIP code-level basement and ground-level exposures during pregnancy and trimesters for each participant's address at birth or delivery. We used logistic regression models, including confounders, to estimate odds ratios (ORs) for term low birth weight in four exposure quartiles (Q1-Q4) with the lowest exposure group (Q1) as the reference.</p><p><strong>Results: </strong>Exposure levels to basement radon throughout pregnancy (0.27-3.02 pCi/L) were below the guideline level set by the US Environmental Protection Agency (4 pCi/L). The ORs for term low birth weight in the second-highest (Q3; 1.01-1.33 pCi/L) exposure group compared with the reference (<0.79 pCi/L) group for basement radon during the first trimester was 1.22 (95% confidence interval [CI] = 1.02, 1.45). The OR in the highest (Q4; 1.34-4.43 pCi/L) quartile group compared with the reference group during the first trimester was 1.26 (95% CI = 1.05, 1.50). Risks from basement radon were higher for participants with lower income, lower maternal education levels, or living in urban regions.</p><p><strong>Conclusion: </strong>This study found increased term low birth weight risks for increases in basement radon. Results have implications for infants' health for exposure to radon at levels below the current national guideline for indoor radon concentrations and building remediations.</p>","PeriodicalId":11779,"journal":{"name":"Epidemiology","volume":" ","pages":"834-843"},"PeriodicalIF":4.7000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560713/pdf/","citationCount":"0","resultStr":"{\"title\":\"Associations Between Gestational Residential Radon Exposure and Term Low Birthweight in Connecticut, USA.\",\"authors\":\"Seulkee Heo, Longxiang Li, Ji-Young Son, Petros Koutrakis, Michelle L Bell\",\"doi\":\"10.1097/EDE.0000000000001771\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Studies suggest biologic mechanisms for gestational exposure to radiation and impaired fetal development. We explored associations between gestational radon exposure and term low birthweight, for which evidence is limited.</p><p><strong>Methods: </strong>We examined data for 68,159 singleton full-term births in Connecticut, United States, 2016-2018. Using a radon spatiotemporal model, we estimated ZIP code-level basement and ground-level exposures during pregnancy and trimesters for each participant's address at birth or delivery. We used logistic regression models, including confounders, to estimate odds ratios (ORs) for term low birth weight in four exposure quartiles (Q1-Q4) with the lowest exposure group (Q1) as the reference.</p><p><strong>Results: </strong>Exposure levels to basement radon throughout pregnancy (0.27-3.02 pCi/L) were below the guideline level set by the US Environmental Protection Agency (4 pCi/L). The ORs for term low birth weight in the second-highest (Q3; 1.01-1.33 pCi/L) exposure group compared with the reference (<0.79 pCi/L) group for basement radon during the first trimester was 1.22 (95% confidence interval [CI] = 1.02, 1.45). The OR in the highest (Q4; 1.34-4.43 pCi/L) quartile group compared with the reference group during the first trimester was 1.26 (95% CI = 1.05, 1.50). Risks from basement radon were higher for participants with lower income, lower maternal education levels, or living in urban regions.</p><p><strong>Conclusion: </strong>This study found increased term low birth weight risks for increases in basement radon. Results have implications for infants' health for exposure to radon at levels below the current national guideline for indoor radon concentrations and building remediations.</p>\",\"PeriodicalId\":11779,\"journal\":{\"name\":\"Epidemiology\",\"volume\":\" \",\"pages\":\"834-843\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560713/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Epidemiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/EDE.0000000000001771\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/7/23 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epidemiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/EDE.0000000000001771","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/23 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Associations Between Gestational Residential Radon Exposure and Term Low Birthweight in Connecticut, USA.
Background: Studies suggest biologic mechanisms for gestational exposure to radiation and impaired fetal development. We explored associations between gestational radon exposure and term low birthweight, for which evidence is limited.
Methods: We examined data for 68,159 singleton full-term births in Connecticut, United States, 2016-2018. Using a radon spatiotemporal model, we estimated ZIP code-level basement and ground-level exposures during pregnancy and trimesters for each participant's address at birth or delivery. We used logistic regression models, including confounders, to estimate odds ratios (ORs) for term low birth weight in four exposure quartiles (Q1-Q4) with the lowest exposure group (Q1) as the reference.
Results: Exposure levels to basement radon throughout pregnancy (0.27-3.02 pCi/L) were below the guideline level set by the US Environmental Protection Agency (4 pCi/L). The ORs for term low birth weight in the second-highest (Q3; 1.01-1.33 pCi/L) exposure group compared with the reference (<0.79 pCi/L) group for basement radon during the first trimester was 1.22 (95% confidence interval [CI] = 1.02, 1.45). The OR in the highest (Q4; 1.34-4.43 pCi/L) quartile group compared with the reference group during the first trimester was 1.26 (95% CI = 1.05, 1.50). Risks from basement radon were higher for participants with lower income, lower maternal education levels, or living in urban regions.
Conclusion: This study found increased term low birth weight risks for increases in basement radon. Results have implications for infants' health for exposure to radon at levels below the current national guideline for indoor radon concentrations and building remediations.
期刊介绍:
Epidemiology publishes original research from all fields of epidemiology. The journal also welcomes review articles and meta-analyses, novel hypotheses, descriptions and applications of new methods, and discussions of research theory or public health policy. We give special consideration to papers from developing countries.