美国康涅狄格州妊娠期住宅氡暴露与足月低出生体重之间的关系。

IF 4.7 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Epidemiology Pub Date : 2024-11-01 Epub Date: 2024-07-23 DOI:10.1097/EDE.0000000000001771
Seulkee Heo, Longxiang Li, Ji-Young Son, Petros Koutrakis, Michelle L Bell
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引用次数: 0

摘要

背景:研究表明,妊娠期暴露于辐射与胎儿发育受损之间存在生物机制。我们探讨了妊娠期氡暴露与足月低出生体重之间的关联,这方面的证据有限:我们研究了 2016-2018 年美国康涅狄格州 68,159 例单胎足月新生儿的数据。利用氡时空模型,我们估算了每位参与者出生或分娩时地址的 ZIP 代码级地下室和地面氡暴露量。我们使用逻辑回归模型(包括混杂因素)估算了四个暴露四分位数(Q1 至 Q4)中足月低出生体重的几率比(ORs),并以最低暴露组(Q1)作为参照:整个孕期的地下室氡暴露水平(0.27-3.02 pCi/L)均低于美国环境保护局设定的指导水平(4 pCi/L)。与参考值相比,第二高(Q3;1.01-1.33 pCi/L)辐照组的足月低出生体重的 ORs(结论:本研究发现,随着地下室氡含量的增加,足月新生儿体重不足的风险也会增加。如果氡暴露水平低于现行的国家室内氡浓度和建筑补救指南,研究结果将对婴儿健康产生影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations Between Gestational Residential Radon Exposure and Term Low Birthweight in Connecticut, USA.

Background: Studies suggest biologic mechanisms for gestational exposure to radiation and impaired fetal development. We explored associations between gestational radon exposure and term low birthweight, for which evidence is limited.

Methods: We examined data for 68,159 singleton full-term births in Connecticut, United States, 2016-2018. Using a radon spatiotemporal model, we estimated ZIP code-level basement and ground-level exposures during pregnancy and trimesters for each participant's address at birth or delivery. We used logistic regression models, including confounders, to estimate odds ratios (ORs) for term low birth weight in four exposure quartiles (Q1-Q4) with the lowest exposure group (Q1) as the reference.

Results: Exposure levels to basement radon throughout pregnancy (0.27-3.02 pCi/L) were below the guideline level set by the US Environmental Protection Agency (4 pCi/L). The ORs for term low birth weight in the second-highest (Q3; 1.01-1.33 pCi/L) exposure group compared with the reference (<0.79 pCi/L) group for basement radon during the first trimester was 1.22 (95% confidence interval [CI] = 1.02, 1.45). The OR in the highest (Q4; 1.34-4.43 pCi/L) quartile group compared with the reference group during the first trimester was 1.26 (95% CI = 1.05, 1.50). Risks from basement radon were higher for participants with lower income, lower maternal education levels, or living in urban regions.

Conclusion: This study found increased term low birth weight risks for increases in basement radon. Results have implications for infants' health for exposure to radon at levels below the current national guideline for indoor radon concentrations and building remediations.

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来源期刊
Epidemiology
Epidemiology 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.70
自引率
3.70%
发文量
177
审稿时长
6-12 weeks
期刊介绍: Epidemiology publishes original research from all fields of epidemiology. The journal also welcomes review articles and meta-analyses, novel hypotheses, descriptions and applications of new methods, and discussions of research theory or public health policy. We give special consideration to papers from developing countries.
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