2017-2019年加拿大城市男同性恋、双性恋和其他男男性行为者口腔人类乳头瘤病毒感染流行率。

IF 5 2区 医学 Q2 IMMUNOLOGY
Jenna Alessandrini, Joseph Cox, Alexandra de Pokomandy, Trevor A Hart, Daniel Grace, Troy Grennan, David Moore, Gilles Lambert, Catharine Chambers, Shelley L Deeks, Ramandip Grewal, Nathan J Lachowsky, Chantal Sauvageau, Darrell H S Tan, François Coutlée, Ann N Burchell
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引用次数: 0

摘要

背景:口腔人乳头瘤病毒(HPV)感染是口咽癌的主要病因。2015 年和 2016 年,HPV 疫苗成为加拿大大多数省份 27 岁以下男同性恋、双性恋和其他男男性行为者(GBM)的公共资助疫苗:方法:2017 年至 2019 年期间,通过受访者驱动的抽样调查,在蒙特利尔、多伦多和温哥华招募了性活跃的 GBM。我们邀请 16 至 30 岁的参与者自行采集口腔漱口水标本进行 HPV 检测。我们估算了口腔中HPV的总体流行率,并根据疫苗接种情况进行了比较:结果:在提供有效口腔标本的 838 名 GBM 中,有 36.9% 的人报告说接种了≥1 剂的 HPV 疫苗。总体而言,至少一种 HPV 类型的口腔 HPV 感染率为 2.6%(95% 置信区间:1.5-3.7%),任何高危类型的口腔 HPV 感染率为 1.2%(95% 置信区间:0.5-1.9%)。在接种过疫苗的人群中,我们检测到了0.3%(95% CI:0.0,1.0%)的四价(HPV 6/11/16/18)疫苗可预防类型,在未接种疫苗的人群中,我们检测到了1.1%(95% CI:0.1,2.0%)的四价疫苗可预防类型:结论:在加拿大城市年轻的 GBM 群体中,口腔 HPV 感染率较低,其中 37% 的人接种了疫苗。研究结果可作为监测疫苗接种对这一重点人群口腔人乳头瘤病毒感染影响的基准。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence of Oral Human Papillomavirus Infection Among Urban Gay, Bisexual, and Other Men Who Have Sex With Men in Canada, 2017-2019.

Background: Oral human papillomavirus (HPV) infections are a leading cause of oropharyngeal cancers. In 2015 and 2016, HPV vaccines became publicly funded for gay, bisexual, and other men who have sex with men (GBM) under 27 years of age in most Canadian provinces.

Methods: Between 2017 and 2019, sexually-active GBM in Montreal, Toronto, and Vancouver were recruited through respondent-driven sampling. Participants aged 16 to 30 years were invited to self-collect oral rinse specimens for HPV testing. We estimated HPV prevalence in the oral tract overall and compared these by vaccination status.

Results: Among the 838 GBM with a valid oral specimen, 36.9% reported receiving ≥1 dose of HPV vaccine. Overall, oral HPV prevalence was 2.6% (95% confidence interval, CI: 1.5, 3.7%) for at least one HPV type and 1.2% (95% CI: 0.5, 1.9%) for any high-risk type. We detected quadrivalent (HPV 6/11/16/18) vaccine-preventable types in 0.3% (95% CI: 0.0, 1.0%) of vaccinated individuals and 1.1% (95% CI: 0.1, 2.0%) in unvaccinated individuals.

Conclusions: Oral HPV prevalence was low in a population of young urban GBM in Canada of whom 37% were vaccinated. Findings serve as a benchmark for monitoring of vaccination impacts on oral HPV infection within this priority population.

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来源期刊
Journal of Infectious Diseases
Journal of Infectious Diseases 医学-传染病学
CiteScore
13.50
自引率
3.10%
发文量
449
审稿时长
2-4 weeks
期刊介绍: Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.
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