研究在圆柱形基底上涂覆聚合物后原位形成孔隙,以实现持续给药。

IF 4.4 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Hao Wei, Ping Lin, Baozhang Shi, Liping Xu, Xiaoping Yang, Wei Sun
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引用次数: 0

摘要

本文基于呼吸图(BF)和气相诱导相分离(VIPS)过程的组合效应,采用一种新颖的原位孔形成策略,在圆柱形基底表面制备了微孔聚乳酸涂层。在高环境湿度条件下,采用氯仿和二甲基甲酰胺这对溶剂对预成型聚乳酸涂层进行后处理,分别按照BF和VIPS的机理诱导孔隙形成。结果得到了一种具有蜂窝状和双连续网络形态的复合多孔结构。通过调节实验因素,包括溶剂对的比例、环境湿度和温度,可以在控制 BF 和 VIPS 机制转换的基础上轻松实现对孔隙形态的操纵。以紫杉醇为模型药物,利用浸泡后的吸附效应将其装载到多孔涂层中。不同形态特征的涂层显示出不同的药物负载和释放能力。28 天释放试验显示了不同涂层样品之间的动态释放曲线,总释放率在 35.70% 到 79.96% 之间。采用 BF-VIPS 复合结构的涂层达到了 19.28 µg cm-2 的最佳载药量和 35.70% 的 28 天释放率。这项研究为构建具有可操控给药特性的药物洗脱涂层确立了一种成本效益高、结构操控灵活的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Study of Manipulative In Situ Pore-Formation upon Polymeric Coating on Cylindrical Substrate for Sustained Drug Delivery.

Herein, the micro-porous polylactic acid coating applied on the surface of the cylindrical substrate is fabricated by a novel in situ pore-formation strategy based on the combinational effect of breath figure (BF) and vapor-induced phase separation (VIPS) processes. Under the condition of high environmental humidity, solvent pair of chloroform and dimethylformamide is employed for post-treatment onto pre-formed PLA coating to induce the pore-formation following the mechanism of BF and VIPS, respectively. A composite porous structure with both cellular-like and bi-continuous network morphologies is obtained. By tunning the experimental factors including the ratio of the solvent pair, environmental humidity, and temperature, morphological manipulation upon the pore morphology can be facilely achieved based on the control of mechanism transition between BF and VIPS. Paclitaxel is used as a model drug and loaded into the porous coating by the wicking effect of post-immersion. Coatings with different morphological features show varying drug loading and release capacities. The 28-day release test reveals dynamic release profiles between different coating samples, with the total release rate ranging from 35.70% to 79.96%. Optimal loading capacity of 19.28 µg cm-2 and 28-day release rate of 35.70% are achieved for the coating with composite BF-VIPS structure. This research established a cost-efficient strategy with high flexibility in the structural manipulation concerning the construction of drug-eluting coating with the feature of manipulative drug delivery.

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来源期刊
Macromolecular bioscience
Macromolecular bioscience 生物-材料科学:生物材料
CiteScore
7.90
自引率
2.20%
发文量
211
审稿时长
1.5 months
期刊介绍: Macromolecular Bioscience is a leading journal at the intersection of polymer and materials sciences with life science and medicine. With an Impact Factor of 2.895 (2018 Journal Impact Factor, Journal Citation Reports (Clarivate Analytics, 2019)), it is currently ranked among the top biomaterials and polymer journals. Macromolecular Bioscience offers an attractive mixture of high-quality Reviews, Feature Articles, Communications, and Full Papers. With average reviewing times below 30 days, publication times of 2.5 months and listing in all major indices, including Medline, Macromolecular Bioscience is the journal of choice for your best contributions at the intersection of polymer and life sciences.
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