Kisspeptins以性双态方式调节小鼠的食物摄入量和运动活动,不受性腺类固醇的影响。

IF 3.3 4区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Inmaculada Velasco, Silvia Daza-Dueñas, Encarnación Torres, Francisco Ruiz-Pino, María J. Vázquez, Manuel Tena-Sempere
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引用次数: 0

摘要

吻肽是生殖轴的重要调节因子,能够有效激活促性腺激素释放激素神经元,同时也是生殖代谢调节的核心通道。最近的证据表明,吻肽本身也可调节一些代谢参数,包括体重、食物摄入量或能量消耗,但其实际作用和作用部位仍不清楚。我们在此进行了一系列研究,探讨了中枢和外周给药吻肽-10(Kp-10;每天分别为 1 nmol 和 3 nmol)对雌雄小鼠 11 天代谢的影响。为了评估Kp-10的直接代谢作用和间接调节性腺激素分泌的作用,我们对性腺切除并分别补充固定生理剂量睾酮或17β-雌二醇的成年雄性和雌性小鼠进行了Kisspeptin作用测试。中枢给药 Kp-10 会降低雄性小鼠的食物摄入量,尤其是在黑暗阶段(约 50%),同时降低总能量消耗和夜间能量消耗(约 16%)以及运动活动(约 70%)。相反,在雌性小鼠中发现了相反的模式,尽管食物摄入或能量消耗没有变化,但总运动量和夜间运动量却增加了(>65%)。这些变化与体重无关,因为在 Kp-10 治疗结束时,雌雄小鼠的体重没有差异。除了雄性小鼠的运动活动减少和雌性小鼠 24 小时食物摄入量的微弱增加外,Kp-10 的外周给药未能改变任何分析的代谢参数,这表明吻肽在能量代谢控制中起着主要的中心作用。最后,糖耐量和胰岛素敏感性并没有受到 Kp-10 中枢或外周处理的显著影响。总之,我们的数据揭示了吻肽在控制关键代谢参数(包括食物摄入、能量消耗和运动活动)中的潜在作用,它优先在中枢水平发挥作用,这种作用与性类固醇无关,但具有性别二态性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Kisspeptins centrally modulate food intake and locomotor activity in mice independently of gonadal steroids in a sexually dimorphic manner

Kisspeptins centrally modulate food intake and locomotor activity in mice independently of gonadal steroids in a sexually dimorphic manner

Kisspeptins are essential regulators of the reproductive axis, with capacity to potently activate gonadotropin-releasing hormone neurons, acting also as central conduits for the metabolic regulation of fertility. Recent evidence suggests that kisspeptins per se may also modulate several metabolic parameters, including body weight, food intake or energy expenditure, but their actual roles and site(s) of action remain unclear. We present herein a series of studies addressing the metabolic effects of central and peripheral administration of kisspeptin-10 (Kp-10; 1 nmol and 3 nmol daily, respectively) for 11 days in mice of both sexes. To assess direct metabolic actions of Kp-10 versus those derived indirectly from its capacity to modulate gonadal hormone secretion, kisspeptin effects were tested in adult male and female mice gonadectomized and supplemented with fixed, physiological doses of testosterone or 17β-estradiol, respectively. Central administration of Kp-10 decreased food intake in male mice, especially during the dark phase (~50%), which was accompanied by a reduction in total and nocturnal energy expenditure (~16%) and locomotor activity (~70%). In contrast, opposite patterns were detected in female mice, with an increase in total and nocturnal locomotor activity (>65%), despite no changes in food intake or energy expenditure. These changes were independent of body weight, as no differences were detected in mice of both sexes at the end of Kp-10 treatments. Peripheral administration of Kp-10 failed to alter any of the metabolic parameters analyzed, except for a decrease in locomotor activity in male mice and a subtle increase in 24 h food intake in female mice, denoting a predominant central role of kisspeptins in the control of energy metabolism. Finally, glucose tolerance and insulin sensitivity were not significantly affected by central or peripheral treatment with Kp-10. In conclusion, our data reveal a potential role of kisspeptins in the control of key metabolic parameters, including food intake, energy expenditure and locomotor activity, with a preferential action at central level, which is sex steroid-independent but sexually dimorphic.

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来源期刊
Journal of Neuroendocrinology
Journal of Neuroendocrinology 医学-内分泌学与代谢
CiteScore
6.40
自引率
6.20%
发文量
137
审稿时长
4-8 weeks
期刊介绍: Journal of Neuroendocrinology provides the principal international focus for the newest ideas in classical neuroendocrinology and its expanding interface with the regulation of behavioural, cognitive, developmental, degenerative and metabolic processes. Through the rapid publication of original manuscripts and provocative review articles, it provides essential reading for basic scientists and clinicians researching in this rapidly expanding field. In determining content, the primary considerations are excellence, relevance and novelty. While Journal of Neuroendocrinology reflects the broad scientific and clinical interests of the BSN membership, the editorial team, led by Professor Julian Mercer, ensures that the journal’s ethos, authorship, content and purpose are those expected of a leading international publication.
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