原发性开角型青光眼和假性角膜剥脱性青光眼患者在 Ex-Press® 手术后 3 年的角膜内皮细胞密度降低情况比较。

IF 1.4 4区医学 Q3 OPHTHALMOLOGY

International Ophthalmology Pub Date : 2024-07-23 DOI:10.1007/s10792-024-03248-w

Hitoshi Yamazaki, Naoki Tojo, Mitsuya Otsuka, Ueda-Consolvo Tomoko, Atsushi Hayashi

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引用次数: 0

摘要

目的：我们比较了原发性开角型青光眼（POAG）和假性角膜剥脱性青光眼（PEX）患者在Ex-Press（EXP）手术后角膜内皮细胞（CED）的损失情况：这是一项单机构回顾性研究。我们纳入了接受 EXP 手术并随访 3 年以上的青光眼患者。我们通过非接触镜检测量了EXP手术前后（12、24和36个月）的CED，并通过配对t检验比较了EXP手术后CED值的平均值和CED存活率：我们纳入了119只接受EXP手术的眼睛，包括60只POAG眼和59只PEX眼。POAG 组的平均 CED 从基线时的 2389 ± 321 降至 3 年后的 2230 ± 424 cells/mm2。PEX 组的平均 CED 从基线时的 2111 ± 510 降至 3 年后的 1845 ± 628 cells/mm2。在 3 年的随访中，POAG 组的 CED 存活率为 93.3 ± 12.5%，而 PEX 组的 CED 存活率明显较低，为 85.0 ± 19.5%（p = 0.0064）。PEX组中有两例出现了大泡性角膜病：EXP手术使PEX患者角膜内皮细胞数量减少的速度快于POAG患者。

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Comparison of corneal endothelial cell density reduction between primary open-angle glaucoma and pseudo-exfoliation glaucoma patients at 3 years after Ex-Press® surgery.

Purpose: We compared corneal endothelial cell (CED) loss after Ex-Press (EXP) surgery between patients with primary open-angle glaucoma (POAG) and pseudo-exfoliation glaucoma (PEX).

Patients and methods: This was a single-facility retrospective study. We included glaucoma patients who had undergone EXP surgery and were followed up > 3 years. We measured the CED before and after (at 12, 24, and 36 months) EXP surgery by noncontact specular microscopy and compared the means of the CED values and CED survival ratios after EXP surgery by paired t-test.

Results: We included 119 eyes that underwent EXP surgery, including 60 POAG eyes and 59 PEX eyes. In the POAG group, the mean CED decreased from 2389 ± 321 at baseline to 2230 ± 424 cells/mm² after 3 years. In the PEX group, the mean CED decreased from 2111 ± 510 at baseline to 1845 ± 628 cells/mm² after 3 years. At the 3-year follow-up, the CED survival ratio was 93.3 ± 12.5% in the POAG group and significantly lower, at 85.0 ± 19.5%, in the PEX group (p = 0.0064). Two cases in the PEX group developed bullous keratopathy.

Conclusions: EXP surgery decreased the corneal endothelial cell populations in PEX patients faster than POAG patients.

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来源期刊

International Ophthalmology OPHTHALMOLOGY-

CiteScore

3.20

自引率

0.00%

发文量

451

期刊介绍： International Ophthalmology provides the clinician with articles on all the relevant subspecialties of ophthalmology, with a broad international scope. The emphasis is on presentation of the latest clinical research in the field. In addition, the journal includes regular sections devoted to new developments in technologies, products, and techniques.