ITIH4 是冠状动脉造影患者冠状动脉血栓的预测因子。

IF 1.6 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Future cardiology Pub Date : 2024-01-01 Epub Date: 2024-07-23 DOI:10.1080/14796678.2024.2377924

Lei Tian, Su Zhao, Ruiyan Zhang

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引用次数: 0

摘要

目的：探讨α-胰蛋白酶间抑制物重链-4（ITIH4）对冠状动脉疾病（CAD）诊断的潜在价值。患者和方法我们招募了接受冠状动脉造影（CAG）检查的患者。采用酶联免疫吸附试验检测血浆 ITIH4。结果显示CAD患者的ITIH4水平低于对照组患者，且与C反应蛋白（CRP）呈负相关。ST段抬高型心肌梗死（STEMI）和非ST段抬高型心肌梗死（NSTEMI）患者的 ITIH4 水平没有差异。逻辑分析证实了 ITIH4 对冠状动脉可见血栓的预测价值。结论ITIH4 可能是诊断 CAD 和预测冠状动脉可见血栓的有用生物标志物。

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ITIH4 is a predictor for coronary thrombus in coronary arteriography patients.

Aim: To explore potential value of inter-alpha-trypsin inhibitor heavy chain-4 (ITIH4) for coronary artery disease (CAD) diagnosis.Patients & methods: We recruited the patients who received coronary arteriography (CAG) examination. The enzyme-linked immunosorbent assay was used to detect plasma ITIH4.Results: ITIH4 level was lower expression in CAD patients than that in patients of control group, and was negatively correlated with C-reactive protein (CRP). ITIH4 level is no differences between ST-elevated myocardial infarction (STEMI) and non-ST-elevated myocardial infarction (NSTEMI) patients. However, its expression was significantly correlated with D-Dimer and thrombin time, and the logistic analysis confirmed predictive value of ITIH4 for visible thrombus in coronary.Conclusion: ITIH4 may be a useful biomarker in CAD diagnosis, and to predict visible thrombus in coronary.

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来源期刊

Future cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.80

自引率

5.90%

发文量

期刊介绍： Research advances have contributed to improved outcomes across all specialties, but the rate of advancement in cardiology has been exceptional. Concurrently, the population of patients with cardiac conditions continues to grow and greater public awareness has increased patients" expectations of new drugs and devices. Future Cardiology (ISSN 1479-6678) reflects this new era of cardiology and highlights the new molecular approach to advancing cardiovascular therapy. Coverage will also reflect the major technological advances in bioengineering in cardiology in terms of advanced and robust devices, miniaturization, imaging, system modeling and information management issues.