口服塞马鲁肽的灵活给药时间在临床实践中实现最大效益的适宜性和实用性:专家小组。

IF 3.8 3区 医学 Q2 Medicine
Diabetes Therapy Pub Date : 2024-09-01 Epub Date: 2024-07-22 DOI:10.1007/s13300-024-01625-3
Riccardo Candido, Chiara Di Loreto, Paolo Desenzani, Paola Pantanetti, Cristina Romano, Silvio Settembrini, Sebastiano Bruno Solerte, Gian Paolo Fadini
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引用次数: 0

摘要

从临床试验和观察数据来看,口服塞马鲁肽已被证明是治疗 2 型糖尿病患者最有效的二线口服疗法。本综述旨在从意大利专家小组的角度,阐述在常规临床护理的自由生活条件下使用口服塞马鲁肽过程中可能出现的挑战。一组意大利专家讨论了口服塞马鲁肽在临床实践中的应用,并提出了自己的见解。主要议题包括口服塞马鲁肽在临床实践中的有效性、优化治疗效果的药物定位、灵活安排给药时间的可能性、遇到的关键问题、患者沟通的作用以及剂量升级和不良反应管理中的信息重要性。报告了随机临床试验和实际研究中关于口服塞马鲁肽疗效和有效性的现有数据,以及决定耐受性和治疗持续性的因素。报告还批判性地探讨了关于固定给药时间与灵活给药时间的争论,并提供了来自小型病例系列和真实世界数据库的轶事线索。此外,还提供了一系列建议,供临床医生在开具口服塞马鲁肽处方时以及在患者监测过程中参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Suitability and Usefulness of a Flexible Dosing Timing of Oral Semaglutide to Maximize Benefit in Clinical Practice: An Expert Panel.

Suitability and Usefulness of a Flexible Dosing Timing of Oral Semaglutide to Maximize Benefit in Clinical Practice: An Expert Panel.

From clinical trials and observational data, oral semaglutide has proven to be the most effective second-line oral therapy for the management of patients with type 2 diabetes. This review aims to describe the perspective of an Italian expert panel that addressed the potential challenges arising during the use of oral semaglutide in the free-living conditions of routine clinical care. A group of Italian experts discussed and generated insights into the use of oral semaglutide in clinical practice. Key topics included the effectiveness of oral semaglutide in clinical practice, the positioning of the agent to optimize the treatment benefits, the possibility to adopt flexibility in the administration schedule, critical issues encountered, the role of patient communication and information in the importance of dose escalation and management of adverse events. Available data on efficacy and effectiveness of oral semaglutide from randomized clinical trials and real-world studies were reported, along with factors that determine tolerability and persistence on treatment. The debate over a fixed versus a flexible dosing schedule was critically addressed, providing anecdotical clues from a small case series and a real-world database. Additionally, a set of recommendations for clinicians to consider when prescribing oral semaglutide and during the process of patient monitoring were provided.

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来源期刊
Diabetes Therapy
Diabetes Therapy Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
6.90
自引率
7.90%
发文量
130
审稿时长
6 weeks
期刊介绍: Diabetes Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all areas of diabetes. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Diabetes Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.
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