透明质酸受体介导的纳米药物和靶向治疗。

IF 9.1 2区材料科学 Q1 CHEMISTRY, PHYSICAL

Small Methods Pub Date : 2024-07-23 DOI:10.1002/smtd.202400513

Qiuhong Ouyang, Ying Zhao, Kunyao Xu, Yuechen He, Meng Qin

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引用次数: 0

摘要

透明质酸（HA）是一种存在于细胞外基质中的天然多糖，在疾病治疗中有着广泛的应用。透明质酸具有良好的生物相容性、生物可降解性以及与各种细胞表面受体相互作用的能力。它的分子量范围广，可修饰的化学基团多，是一种有效的药物载体。此外，在许多疾病状态下，HA 的特异性受体在细胞表面过度表达，通过受体结合增强了药物在病理部位的蓄积。本综述概述了药物对 HA 的修饰、主要受体蛋白以及用于治疗肿瘤和炎症性疾病的受体靶向纳米给药系统（DDS）的最新进展。此外，还讨论了不同分子量的 HA 在体内的功能以及针对不同疾病的给药方法选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Hyaluronic Acid Receptor-Mediated Nanomedicines and Targeted Therapy

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Hyaluronic Acid Receptor-Mediated Nanomedicines and Targeted Therapy

Hyaluronic acid (HA) is a naturally occurring polysaccharide found in the extracellular matrix with broad applications in disease treatment. HA possesses good biocompatibility, biodegradability, and the ability to interact with various cell surface receptors. Its wide range of molecular weights and modifiable chemical groups make it an effective drug carrier for drug delivery. Additionally, the overexpression of specific receptors for HA on cell surfaces in many disease states enhances the accumulation of drugs at pathological sites through receptor binding. In this review, the modification of HA with drugs, major receptor proteins, and the latest advances in receptor-targeted nano drug delivery systems (DDS) for the treatment of tumors and inflammatory diseases are summarized. Furthermore, the functions of HA with varying molecular weights of HA in vivo and the selection of drug delivery methods for different diseases are discussed.

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来源期刊

Small Methods Materials Science-General Materials Science

CiteScore

17.40

自引率

1.60%

发文量

347

期刊介绍： Small Methods is a multidisciplinary journal that publishes groundbreaking research on methods relevant to nano- and microscale research. It welcomes contributions from the fields of materials science, biomedical science, chemistry, and physics, showcasing the latest advancements in experimental techniques. With a notable 2022 Impact Factor of 12.4 (Journal Citation Reports, Clarivate Analytics, 2023), Small Methods is recognized for its significant impact on the scientific community. The online ISSN for Small Methods is 2366-9608.