表达汉坦病毒心肺综合征和出血热伴肾综合征的包膜糖蛋白的生物信息学分析

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-18 DOI:10.2174/0115734110297618240703113456

Carlos Polanco, Alberto Huberman, Vladimir N. Uversky, Martha Rios Castro, Enrique Hernández-Lemus, Thomas Buhse, Gilberto Vargas Alarcón, Gabriela Calvo-Leroux Corona, Erika Jeannette López Oliva, Claudia Pimentel- Hernández, Mireya Martínez-Garcia, Brayans Becerra-Luna, Juan Luciano Díaz González, Raul Martinez-Memije, Francisco J. Roldan Gomez, Pedro L. Flores Ch, Carlos Rafael Sierra Fernández

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引用次数: 0

摘要

背景：汉坦病毒通过啮齿动物传播与严重疾病的发生有关，包括心肺综合征（CPS）和出血热伴肾综合征（HFRS）。影响啮齿动物种群的环境变化会影响它们在全球的分布。这些都是严重的疾病，具有潜在的致命性，而且分布广泛，是一个公共卫生问题。研究目的进行计算研究是为了更好地了解汉坦病毒表达的包膜糖蛋白，这些糖蛋白会产生心肺综合征和出血热伴肾综合征：为了更好地了解汉坦病毒表达的包膜糖蛋白，并将其视为心肺综合征和出血热伴肾综合征糖蛋白，进行了计算研究。方法：通过使用特定的计算工具，包括内在紊乱倾向（PIDP）、极性指数法简介 3.0v（PIM 3.0v）和基因组学软件，找到了糖蛋白序列。结果通过研究 PIM 3.0v 和 PIDP 图谱，发现了不同基因型汉坦病毒包膜糖蛋白的不同模式。通过这些模式可以确定结构和形态上的相似性。特别是，PIM 3.0v 图谱显示可以区分 CPS 和 HFRS 组，而 PIDP 图谱显示与 CPS 和 HFRS 相关的汉坦病毒毒株的糖蛋白 N 和 C 存在重叠紊乱图谱。结论利用 PIM 3.0v 图谱，我们的计算机程序能够鉴定出与心肺综合征和出血热伴肾综合征相关的汉坦病毒包膜糖蛋白分离物。我们相信这项研究有助于深入了解这些新出现的病毒。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A Bioinformatics Analysis of the Envelope Glycoproteins Expressing the Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever with Renal Syndrome

Background: The transmission of hantaviruses through rodents has been associated with the development of severe illnesses, including Cardiopulmonary Syndrome (CPS) and Hemorrhagic Fever with Renal Syndrome (HFRS). Environmental changes impacting rodent populations affect their global distribution. These are severe diseases, potentially lethal, and widespread, making them a public health issue. Objective: Computational studies were conducted to better understand the envelope glycoproteins that are expressed by Hantavirus, which produce the cardiopulmonary syndrome and the hemorrhagic fever with renal syndrome. objective: Computational studies were conducted in order to better understand the envelope glycoproteins that are expressed by Hantavirus, and which are considered as cardiopulmonary syndrome and hemorrhagic fever with renal syndrome glycoproteins. Methods: The glycoprotein sequences were found through the utilization of specific computational tools, including the Intrinsic Disorder Predisposition (PIDP), Polarity Index Method Profile 3.0v (PIM 3.0v), and genomics software. Results: Examining the PIM 3.0v profile and the PIDP profile revealed distinct patterns in the envelope glycoproteins of different genotypes of Hantavirus. These patterns allowed for structural and morphological similarities to be identified. In particular, the PIM 3.0v profile shows that it is possible to discriminate between CPS and HFRS groups, and the PIDP profile shows the existence of an overlaid disorder profile of glycoproteins N and C from Hantavirus strains associated with CPS and HFRS. Conclusion: Using the PIM 3.0v profile, our computer programs were able to identify isolates of Hantavirus envelope glycoproteins associated with cardiopulmonary syndrome and hemorrhagic fever with renal syndrome. We believe this research contributes to a deeper comprehension of these emerging viruses.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.