用于青少年特发性脊柱侧凸的可重构、可愈合和可回收的 3D 打印矫形器

IF 6 2区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Xiu-Chong He, Jian-Cheng Lai, Peng-Fei Zheng and Cheng-Hui Li
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引用次数: 0

摘要

青少年特发性脊柱侧弯(AIS)是一种结构性疾病,会给患者带来精神和肉体上的双重痛苦。如今,3D 打印脊柱侧弯矫形器对 AIS 的治疗有很好的效果。由于矫形过程中体形的变化,一个完整的疗程需要许多矫形器才能适合患者,这不仅会增加医疗费用,还会对环境造成大量不可降解的污染物。因此,可重新配置和可回收的 3D 打印矫形器是可取的。然而,这种矫形器的材料设计从根本上就具有挑战性。在此,我们通过在双功能光活性丙烯酸酯单体中加入二硫键,并使用二硫苏糖醇加速二硫键交换,获得了一种坚硬、可重构、可回收、可愈合的聚合物,并可三维打印成矫形器。这种制备好的聚合物具有很高的机械强度(363.2 兆帕的杨氏模量和 146.3% 的最大伸长率)和出色的动态特性(可在 100 °C 下重新加工,溶解在含硫醇的溶剂中后可回收,加热后可愈合)。利用这种聚合物的三维打印技术制造的矫形器可以通过不断重新配置来适应患者的身体,从而提高治疗 AIS 的效果。此外,这些矫形器在使用后还可以回收,因此可以大大减少医疗废物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A reconfigurable, healable and recyclable 3D printed orthosis for adolescent idiopathic scoliosis†

A reconfigurable, healable and recyclable 3D printed orthosis for adolescent idiopathic scoliosis†

Adolescent idiopathic scoliosis (AIS) is a structural illness, which causes both mental and physical pain in patients. Nowadays, 3D-printed scoliosis orthoses are effective in AIS treatment. Owing to the change in the body shape during orthopedic procedures, a complete course of treatment will need many orthoses to fit patients, which will increase medical expense and result in a large amount of nondegradable waste, thereby polluting the environment. Therefore, reconfigurable and recyclable 3D printed orthoses are desirable. However, the design of materials for such orthoses is fundamentally challenging. Herein, by incorporating disulfide bonds into a bifunctional photoactive acrylate monomer and using dithiothreitol to accelerate disulfide bond exchange, we obtained a stiff yet reconfigurable, recyclable, healable polymer that can be 3D printed into orthoses. This as-prepared polymer demonstrated a high mechanical strength (363.2 MPa Young's modulus and 146.3% maximum elongation) and excellent dynamic properties (reprocessable at 100 °C, recyclable upon dissolving in thiol-containing solvents, and healable upon heating). Orthoses manufactured via the 3D printing of this polymer can adapt to a patient's body through continuous reconfiguration, thus improving their effectiveness in treating AIS. Moreover, these orthoses can be recycled after use, and thus, medical waste can be significantly reduced.

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来源期刊
Materials Chemistry Frontiers
Materials Chemistry Frontiers Materials Science-Materials Chemistry
CiteScore
12.00
自引率
2.90%
发文量
313
期刊介绍: Materials Chemistry Frontiers focuses on the synthesis and chemistry of exciting new materials, and the development of improved fabrication techniques. Characterisation and fundamental studies that are of broad appeal are also welcome. This is the ideal home for studies of a significant nature that further the development of organic, inorganic, composite and nano-materials.
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