治疗难治性腐蚀性食管狭窄的区域内类固醇。

M Martínez Díaz, V Ibáñez Pradas, M Couselo Jerez, E Valdés Diéguez, I Viguria Marco
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引用次数: 0

摘要

摘要材料与方法:对难治性腐蚀性食管狭窄患者进行局部类固醇治疗的疗效进行分析:对因难治性腐蚀性食管狭窄而接受曲安奈德类固醇治疗的患者进行了一项分析性、回顾性研究。研究人员收集了治疗前后的人口统计学变量、狭窄特征、扩张次数、类固醇注射次数和扩张评分(扩张次数/随访月数)。采用 T 检验或 Wilcoxon 检验比较治疗前后的狭窄特征(直径和长度)和扩张评分:N= 5.中位年龄:5 岁(17 个月-7 岁)。随访时间:6.60 ± 2.70 年。吞咽的产物包括 NaOH、KOH 和 ClH。随访开始时,Zargar分类为IIb(n= 2)、IIIa(n= 1)和两个慢性狭窄。类固醇治疗开始前进行了 6.6 ± 9.23 次食管扩张。内部治疗的平均次数为(11.20 ± 6.14)次。狭窄长度减少了 3.60 ± 2.63 厘米(t= 3.06;p= 0.019)。在直径增加方面没有发现差异:-1.60±3.58毫米(t=-1.00;p= 0.187)。随访一个月的扩张评分从 1.47 ± 0.86 降至 0.47 ± 0.18(Z= -2.02;P= 0.043):结论:尽管在儿科人群中可用的证据有限,但局部曲安奈德治疗对治疗难治性腐蚀性食管狭窄似乎很有用,因为它能减少食管长度和扩张评分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Intralesional steroids in refractory caustic esophageal stricture.

Objective: To analyze the efficacy of intralesional steroid treatment in refractory caustic esophageal stricture.

Materials and methods: An analytical, retrospective study of patients receiving intralesional steroid treatment with triamcinolone acetonide as a result of refractory caustic esophageal stricture was carried out. Demographic variables, stricture characteristics, number of dilations, steroid injections, and dilation score (no. of dilations/follow-up period in months) pre- and post-treatment were collected. Stricture characteristics (diameter and length) and dilation score pre- and post-treatment were compared using the T-Test or Wilcoxon test.

Results: N= 5. Median age: 5 years (17 months-7 years). Follow-up: 6.60 ± 2.70 years. Swallowed products included NaOH, KOH, and ClH. Zargar classification at follow-up initiation was IIb (n= 2), IIIa (n= 1), and two chronic strictures. 6.6 ± 9.23 esophageal dilations were carried out before steroid treatment initiation. The mean number of intralesional therapy sessions was 11.20 ± 6.14. Stricture length decreased by 3.60 ± 2.63 cm (t= 3.06; p= 0.019). No differences were found in terms of diameter increase: -1.60 ± 3.58 mm (t= -1.00; p= 0.187). The dilation score diminished from 1.47 ± 0.86 to 0.47 ± 0.18 dilations per month of follow-up (Z= -2.02; p= 0.043).

Conclusions: Even though there is limited evidence available in the pediatric population, intralesional triamcinolone treatment is seemingly useful in the treatment of refractory caustic esophageal stricture, since it reduces length and dilation score.

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