肠道核苷酸代谢的 SIRT 化。

IF 11.4 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Trends in Endocrinology and Metabolism Pub Date : 2024-09-01 Epub Date: 2024-07-20 DOI:10.1016/j.tem.2024.07.003

Shweta Tiwary, Cristina D Guerena, Jenna L Jewell

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引用次数: 0

摘要

肠道是一个增殖组织，会受到各种干扰其平衡的压力。Tucker 等人最近的一项研究表明，在电离辐射（IR）后，肿瘤抑制因子 SIRT4 的缺失会导致细胞通过新核苷酸生物合成途径而非挽救途径增殖。

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SIRTifying intestinal nucleotide metabolism.

The intestine is a proliferative tissue subjected to a variety of stresses that disturb its homeostasis. A recent study by Tucker et al. demonstrated that loss of the tumor suppressor SIRT4 leads to increased cell proliferation via the de novo nucleotide biosynthesis pathway over the salvage pathway after ionizing irradiation (IR).

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来源期刊

Trends in Endocrinology and Metabolism 医学-内分泌学与代谢

CiteScore

20.10

自引率

0.00%

发文量

审稿时长

82 days

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