蛋白酶体抑制剂对犬尿道癌的抗肿瘤作用

IF 1.1 4区农林科学 Q3 VETERINARY SCIENCES

Journal of Veterinary Medical Science Pub Date : 2024-09-01 Epub Date: 2024-07-19 DOI:10.1292/jvms.23-0094

Yuka Kodera, Takaaki Iguchi, Daiki Kato, Namiko Ikeda, Masahiro Shinada, Susumu Aoki, Kyoka Soga, Toshio Li, Ryosuke Ohata, Shoma Koseki, Hayato Shibahara, Yosuke Takahashi, Yuko Hashimoto, Ryohei Nishimura, Takayuki Nakagawa

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引用次数: 0

摘要

犬尿路上皮癌（cUC）是影响犬的最严重的恶性肿瘤之一，但其增殖机制尚未完全阐明。泛素-蛋白酶体系统（UPS）是调节蛋白质降解的重要代谢途径，其功能障碍会导致细胞凋亡。我们研究了蛋白酶体抑制剂硼替佐米的抗肿瘤作用。硼替佐米在体外通过诱导细胞凋亡抑制了cUC细胞系的细胞生长。这些研究结果表明，硼替佐米有可能成为治疗狗膀胱癌的新型药物。

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Anti-tumor effect of proteasome inhibitor on canine urothelial carcinoma.

Canine urothelial carcinoma (cUC) is one of the most malignant tumors affecting dogs; however, its proliferative mechanism is yet to be fully elucidated. The ubiquitin-proteasome system (UPS) is an important metabolic pathway regulating protein degradation, and its dysfunction leads to apoptosis. We investigated the antitumor effect of the proteasome inhibitor bortezomib, which blocks the UPS. Bortezomib inhibited cell growth in cUC cell lines by inducing apoptosis in vitro. These findings suggest the potential of bortezomib as a novel therapeutic drug for dogs with cUC.

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来源期刊

Journal of Veterinary Medical Science 农林科学-兽医学

CiteScore

2.30

自引率

8.30%

发文量

230

审稿时长

9-18 weeks

期刊介绍： JVMS is a peer-reviewed journal and publishes a variety of papers on veterinary science from basic research to applied science and clinical research. JVMS is published monthly and consists of twelve issues per year. Papers are from the areas of anatomy, physiology, pharmacology, toxicology, pathology, immunology, microbiology, virology, parasitology, internal medicine, surgery, clinical pathology, theriogenology, avian disease, public health, ethology, and laboratory animal science. Although JVMS has played a role in publishing the scientific achievements of Japanese researchers and clinicians for many years, it now also accepts papers submitted from all over the world.