Yumi Minyi Yao, Irina Miodownik, Michael P O'Hagan, Muhammad Jbara, Ariel Afek
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引用次数: 0
摘要
转录因子(TFs)复杂地穿梭于庞大的基因组中,定位并结合特定的 DNA 序列,以调节基因表达程序。这些相互作用发生在动态的细胞环境中,在这种环境中,DNA 和转录因子蛋白不断经历化学和结构扰动,包括表观遗传修饰、DNA 损伤、机械应力和翻译后修饰 (PTM)。虽然这些因素中有很多都会影响 TF-DNA 结合的相互作用,但了解它们的影响仍然具有挑战性且不全面。本综述探讨了有关这些动态变化及其对 TF-DNA 相互作用的潜在影响的现有文献。
Deciphering the dynamic code: DNA recognition by transcription factors in the ever-changing genome.
Transcription factors (TFs) intricately navigate the vast genomic landscape to locate and bind specific DNA sequences for the regulation of gene expression programs. These interactions occur within a dynamic cellular environment, where both DNA and TF proteins experience continual chemical and structural perturbations, including epigenetic modifications, DNA damage, mechanical stress, and post-translational modifications (PTMs). While many of these factors impact TF-DNA binding interactions, understanding their effects remains challenging and incomplete. This review explores the existing literature on these dynamic changes and their potential impact on TF-DNA interactions.