老年抗磷脂综合征的特征和预后:一项观察性队列研究

IF 1.9 4区 医学 Q3 RHEUMATOLOGY
Lupus Pub Date : 2024-09-01 Epub Date: 2024-07-21 DOI:10.1177/09612033241266875
Liang Luo, Qingmeng Cai, Xiangjun Liu, Zelin Yun, Xuerong Li, Rui Yan, Chun Li
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引用次数: 0

摘要

目的:抗磷脂综合征(APS)是一种主要影响年轻人的自身免疫性疾病:抗磷脂综合征(APS)是一种主要影响年轻人的自身免疫性疾病。建议对怀疑患有 APS 的年轻患者进行抗磷脂抗体检测。然而,在老年APS患者中,很难将APS与其他获得性血栓性疾病区分开来。本研究旨在探讨老年型APS的特征和预后:这是一项观察性队列研究。纳入2009年至2022年间接受随访的血栓性APS患者。将老年APS患者(发病年龄≥60岁)与非老年APS患者(发病年龄≥60岁)进行比较:本研究共纳入 161 例 APS 患者,其中 45 例(28.0%)为老年型 APS。中风(35.6% vs. 18.1%,p = .018)在老年型 APS 患者发病时更为常见。与非老年型患者相比,老年型 APS 患者的心血管风险因素更多。老年 APS 患者的狼疮抗凝物阳性率(51.1% vs. 71.6%,p = .014)和比率[1.24 (1.01-1.38) vs. 1.37 (1.16-1.77),p = .004]均明显较低。老年APS患者的10年累积全因死亡率(p < .001)和APS相关死亡率明显高于非老年APS患者(p = .002)和老年非APS患者(p = .040):结论:老年 APS 患者具有独特的疾病特征,其 10 年累积全因死亡率和 APS 相关死亡率较高。早期识别和控制合并症可降低老年 APS 患者的血栓复发率和死亡率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Characteristics and prognosis of elderly-onset antiphospholipid syndrome: An observational cohort study.

Objective: Antiphospholipid syndrome (APS) is an autoimmune disease mainly affecting young individuals. Testing for antiphospholipid antibodies is recommended for young patients who are suspected to have APS. Yet, it is hard to differentiate APS from other acquired thrombophilia disorders in elderly-onset APS patients. This study aim to investigate the characteristics and prognosis of elderly-onset APS.

Methods: This is an observational cohort study. Thrombotic APS patients who underwent follow-ups between 2009 and 2022 were included. Elderly-onset APS patients (onset age ≥60 years) were compared to non-elderly-onset APS patients (onset age <60 years) and matched cases of elderly non-APS patients (age ≥60 years with thrombosis).

Results: A total of 161 APS patients were included in this study, 45 (28.0%) were elderly-onset APS. Stroke (35.6% vs. 18.1%, p = .018) was more common at disease onset in elderly-onset APS patients. Compared to non-elderly-onset patients, elderly-onset APS patients were associated with a higher number of cardiovascular risk factors. Elderly-onset APS patients showed significantly lower positive rate (51.1% vs. 71.6%, p = .014) and ratios [1.24 (1.01-1.38) vs. 1.37 (1.16-1.77), p = .004] of lupus anticoagulant. Elderly-onset APS patients had a significantly higher 10-years cumulative all-cause mortality (p < .001) and APS-related mortality than non-elderly-onset patients (p = .002) and elderly non-APS patients (p = .040).

Conclusions: Elderly-onset APS patients have unique disease characteristics with higher 10-years cumulative all-cause mortality and APS-related mortality. Early recognition and control of comorbidities may reduce the recurrence of thrombosis and mortality in elderly-onset APS patients.

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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
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