类风湿性关节炎患者坚持服用甲氨蝶呤的预测因素、患者对甲氨蝶呤的认识及其对生活质量的影响。

IF 3.3 Q1 HEALTH POLICY & SERVICES
Journal of Pharmaceutical Policy and Practice Pub Date : 2024-07-18 eCollection Date: 2024-01-01 DOI:10.1080/20523211.2024.2365933
Marwa Mohamed, Abd El-Maboud, Heba F Salem, Mohamed N Salem, Mahmoud Abo Elmaaty, Nermin Eissa, Amira S A Said, Raghda R S Hussein
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引用次数: 0

摘要

导言:埃及和整个中东地区缺乏对类风湿性关节炎(RA)患者依从性的研究。本研究旨在评估类风湿性关节炎(RA)患者服用甲氨蝶呤(MTX)的依从性,并找出特定的不依从性预测因素:这项横断面观察性研究纳入了 300 名接受 MTX 治疗至少一年的 RA 患者。调查通过直接访谈完成。调查收集了患者的人口统计学数据(年龄、教育程度、性别、工作状况、病程、MTX用药时间和当前剂量)。研究还评估了患者对 MTX 的依从性、MTX 副作用和功能障碍的预测因素:大多数受访者对MTX的依从性良好,50%以上的患者出现过MTX副作用。大部分受访者对 MTX 的性质和副作用知之甚少。大多数受访者表示在与生活质量相关的活动和功能障碍方面没有遇到困难或遇到一些困难:结论:MTX 的依从性和认知度与许多变量呈正相关,包括年龄、教育水平和病程,这反过来又对患者的生活质量产生了积极影响。但仍需开展更多研究,以确定不依从性对患者健康结果的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Predictors of methotrexate adherence and patient's awareness of it in rheumatoid arthritis and its effect on quality of life.

Introduction: Adherence studies among rheumatoid arthritis (RA) patients, in Egypt and throughout the Middle East region, are lacking. This study aimed to evaluate methotrexate (MTX) adherence in Rheumatoid arthritis (RA) patients and to identify specific non-adherence predictors.

Methods: A cross-sectional observational study included 300 RA patients who were administered MTX for at least one year. The survey was completed through direct interviews. The demographic patient data were collected (age, education, sex, work status, disease duration, duration of MTX administration and current dose). Patients' adherence to MTX predictors for non-adherence, MTX side effects and functional disability were assessed in the study.

Results: Majority of respondents showed good MTX adherence, and more than 50% of patient's experienced MTX side effects. A large percentage of participants showed low knowledge about MTX nature and side effects. Most participants reported no or some difficulty in quality of life-related activities and functional disability.

Conclusion: MTX adherence and awareness were positively correlated to many variables, including, age, educational level and disease duration, which in turn has its positive impact on the patient's quality of life. Still, more research is needed to determine the impact of non-adherence on the patient's health outcomes.

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来源期刊
Journal of Pharmaceutical Policy and Practice
Journal of Pharmaceutical Policy and Practice Health Professions-Pharmacy
CiteScore
4.70
自引率
9.50%
发文量
81
审稿时长
14 weeks
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