利用 UPLC-ESI-Orbitrap-MS 技术进行亲和超滤筛选，从天然产品中筛选 GLP-1r 激动剂：三七案例研究。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-07-22 DOI:10.1080/10286020.2024.2378821

Hong-Ping Wang, Zhao-Zhou Lin, Qiong Yin, Jing Du

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引用次数: 0

摘要

我们的研究建立了一种基于亲和超滤筛选结合UPLC-ESI-Orbitrap-MS技术从天然产物中筛选胰高血糖素样肽-1受体（GLP-1R）激动剂的方法，并以我们建立的方法从三七中筛选出的GLP-1R激动剂为例。结果，首次从三七中筛选出了五种 GLP-1R 激动剂。我们的研究结果表明，激活GLP-1R促进胰岛素分泌可能是人参中人参皂苷的另一重要降血糖机制，这对研究人参皂苷的抗糖尿病作用具有重要影响。

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Screening of GLP-1r agonists from natural products using affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS technology: a case study of Panax ginseng.

In our study, a method based on affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS technology was established to select Glucagon-like peptide-1 receptor (GLP-1R) agonists from natural products, and as an example, the GLP-1R agonists from Panax ginseng was selected using our established method. As a result, total five GLP-1R agonists were selected from Panax ginseng for the first time. Our results indicated that activating GLP-1R to promote insulin secretion probably was another important hypoglycemia mechanism for ginsenosides in Panax ginseng, which had great influence on the study of the anti-diabetes effect of ginsenosides.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.