Megan C Hansel, Abigail M Rosenberg, Carolyn W Kinkade, Camila Capurro, Zorimar Rivera-Núñez, Emily S Barrett
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引用次数: 0
摘要
审查目的:许多合成的干扰内分泌的化学物质(EDCs)在环境中无处不在,在孕妇中的检出率也很高。这些化学物质可能会干扰母体和/或胎儿的性类固醇激素,而这些激素对妊娠维持和胎儿发育至关重要。在此,我们回顾了流行病学文献,研究了产前接触常见合成 EDC 与母体和胎儿性类固醇激素的关系:我们使用 PubMed、SCOPUS 和 Embase 进行了文献检索,最终确定了 29 篇文章进行全面审查。酚类、对羟基苯甲酸酯类和持久性有机污染物通常与雄激素、雌激素和孕酮呈反向关系。邻苯二甲酸盐和全氟及多氟烷基物质与孕酮呈反向关系,而雄激素和雌激素方面的证据则不尽相同。根据胎儿性别和接触时间/结果,观察到了不一致但值得注意的差异。总体而言,文献表明 EDC 可能会干扰母体和胎儿的性类固醇活性,但研究结果不一。鉴于这些合成化学物质的普遍、大量生产以及性类固醇激素在妊娠期间发挥的关键作用,有必要开展更多的研究。
Exposure to Synthetic Endocrine-Disrupting Chemicals in Relation to Maternal and Fetal Sex Steroid Hormones: A Scoping Review.
Purpose of review: Many synthetic endocrine-disrupting chemicals (EDCs) are ubiquitous in the environment and highly detected among pregnant people. These chemicals may disrupt maternal and/or fetal sex steroid hormones, which are critical to pregnancy maintenance and fetal development. Here, we review the epidemiological literature examining prenatal exposure to common synthetic EDCs in relation to maternal and fetal sex steroid hormones.
Recent findings: We performed a literature search using PubMed, SCOPUS, and Embase, ultimately identifying 29 articles for full review. Phenols, parabens, and persistent organic pollutants generally showed inverse associations with androgens, estrogens, and progesterone. Phthalates and per-and polyfluoroalkyl substances tended to be inversely associated with progesterone, while evidence regarding androgens and estrogens was mixed. Inconsistent, but noteworthy, differences by fetal sex and timing of exposure/outcome were observed. Overall, the literature suggests EDCs may disrupt maternal and fetal sex steroid activity, though findings are mixed. Given the pervasive, high-volume production of these synthetic chemicals and the critical functions sex steroid hormones play during gestation, additional research is warranted.
期刊介绍:
Current Environmental Health Reports provides up-to-date expert reviews in environmental health. The goal is to evaluate and synthesize original research in all disciplines relevant for environmental health sciences, including basic research, clinical research, epidemiology, and environmental policy.