合成干扰内分泌的化学品暴露与母体和胎儿性类固醇激素的关系:范围综述》。

IF 7.4 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Current Environmental Health Reports Pub Date : 2024-09-01 Epub Date: 2024-07-22 DOI:10.1007/s40572-024-00455-6
Megan C Hansel, Abigail M Rosenberg, Carolyn W Kinkade, Camila Capurro, Zorimar Rivera-Núñez, Emily S Barrett
{"title":"合成干扰内分泌的化学品暴露与母体和胎儿性类固醇激素的关系:范围综述》。","authors":"Megan C Hansel, Abigail M Rosenberg, Carolyn W Kinkade, Camila Capurro, Zorimar Rivera-Núñez, Emily S Barrett","doi":"10.1007/s40572-024-00455-6","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>Many synthetic endocrine-disrupting chemicals (EDCs) are ubiquitous in the environment and highly detected among pregnant people. These chemicals may disrupt maternal and/or fetal sex steroid hormones, which are critical to pregnancy maintenance and fetal development. Here, we review the epidemiological literature examining prenatal exposure to common synthetic EDCs in relation to maternal and fetal sex steroid hormones.</p><p><strong>Recent findings: </strong>We performed a literature search using PubMed, SCOPUS, and Embase, ultimately identifying 29 articles for full review. Phenols, parabens, and persistent organic pollutants generally showed inverse associations with androgens, estrogens, and progesterone. Phthalates and per-and polyfluoroalkyl substances tended to be inversely associated with progesterone, while evidence regarding androgens and estrogens was mixed. Inconsistent, but noteworthy, differences by fetal sex and timing of exposure/outcome were observed. Overall, the literature suggests EDCs may disrupt maternal and fetal sex steroid activity, though findings are mixed. Given the pervasive, high-volume production of these synthetic chemicals and the critical functions sex steroid hormones play during gestation, additional research is warranted.</p>","PeriodicalId":10775,"journal":{"name":"Current Environmental Health Reports","volume":" ","pages":"356-379"},"PeriodicalIF":7.4000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11324767/pdf/","citationCount":"0","resultStr":"{\"title\":\"Exposure to Synthetic Endocrine-Disrupting Chemicals in Relation to Maternal and Fetal Sex Steroid Hormones: A Scoping Review.\",\"authors\":\"Megan C Hansel, Abigail M Rosenberg, Carolyn W Kinkade, Camila Capurro, Zorimar Rivera-Núñez, Emily S Barrett\",\"doi\":\"10.1007/s40572-024-00455-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose of review: </strong>Many synthetic endocrine-disrupting chemicals (EDCs) are ubiquitous in the environment and highly detected among pregnant people. These chemicals may disrupt maternal and/or fetal sex steroid hormones, which are critical to pregnancy maintenance and fetal development. Here, we review the epidemiological literature examining prenatal exposure to common synthetic EDCs in relation to maternal and fetal sex steroid hormones.</p><p><strong>Recent findings: </strong>We performed a literature search using PubMed, SCOPUS, and Embase, ultimately identifying 29 articles for full review. Phenols, parabens, and persistent organic pollutants generally showed inverse associations with androgens, estrogens, and progesterone. Phthalates and per-and polyfluoroalkyl substances tended to be inversely associated with progesterone, while evidence regarding androgens and estrogens was mixed. Inconsistent, but noteworthy, differences by fetal sex and timing of exposure/outcome were observed. Overall, the literature suggests EDCs may disrupt maternal and fetal sex steroid activity, though findings are mixed. Given the pervasive, high-volume production of these synthetic chemicals and the critical functions sex steroid hormones play during gestation, additional research is warranted.</p>\",\"PeriodicalId\":10775,\"journal\":{\"name\":\"Current Environmental Health Reports\",\"volume\":\" \",\"pages\":\"356-379\"},\"PeriodicalIF\":7.4000,\"publicationDate\":\"2024-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11324767/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Environmental Health Reports\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s40572-024-00455-6\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/7/22 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Environmental Health Reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s40572-024-00455-6","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/22 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
引用次数: 0

摘要

审查目的:许多合成的干扰内分泌的化学物质(EDCs)在环境中无处不在,在孕妇中的检出率也很高。这些化学物质可能会干扰母体和/或胎儿的性类固醇激素,而这些激素对妊娠维持和胎儿发育至关重要。在此,我们回顾了流行病学文献,研究了产前接触常见合成 EDC 与母体和胎儿性类固醇激素的关系:我们使用 PubMed、SCOPUS 和 Embase 进行了文献检索,最终确定了 29 篇文章进行全面审查。酚类、对羟基苯甲酸酯类和持久性有机污染物通常与雄激素、雌激素和孕酮呈反向关系。邻苯二甲酸盐和全氟及多氟烷基物质与孕酮呈反向关系,而雄激素和雌激素方面的证据则不尽相同。根据胎儿性别和接触时间/结果,观察到了不一致但值得注意的差异。总体而言,文献表明 EDC 可能会干扰母体和胎儿的性类固醇活性,但研究结果不一。鉴于这些合成化学物质的普遍、大量生产以及性类固醇激素在妊娠期间发挥的关键作用,有必要开展更多的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exposure to Synthetic Endocrine-Disrupting Chemicals in Relation to Maternal and Fetal Sex Steroid Hormones: A Scoping Review.

Purpose of review: Many synthetic endocrine-disrupting chemicals (EDCs) are ubiquitous in the environment and highly detected among pregnant people. These chemicals may disrupt maternal and/or fetal sex steroid hormones, which are critical to pregnancy maintenance and fetal development. Here, we review the epidemiological literature examining prenatal exposure to common synthetic EDCs in relation to maternal and fetal sex steroid hormones.

Recent findings: We performed a literature search using PubMed, SCOPUS, and Embase, ultimately identifying 29 articles for full review. Phenols, parabens, and persistent organic pollutants generally showed inverse associations with androgens, estrogens, and progesterone. Phthalates and per-and polyfluoroalkyl substances tended to be inversely associated with progesterone, while evidence regarding androgens and estrogens was mixed. Inconsistent, but noteworthy, differences by fetal sex and timing of exposure/outcome were observed. Overall, the literature suggests EDCs may disrupt maternal and fetal sex steroid activity, though findings are mixed. Given the pervasive, high-volume production of these synthetic chemicals and the critical functions sex steroid hormones play during gestation, additional research is warranted.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
13.60
自引率
1.30%
发文量
47
期刊介绍: Current Environmental Health Reports provides up-to-date expert reviews in environmental health. The goal is to evaluate and synthesize original research in all disciplines relevant for environmental health sciences, including basic research, clinical research, epidemiology, and environmental policy.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信