偏头痛残疾评估（MIDAS）的最小重要差异：来自 DMKG 头痛登记处的纵向数据。

IF 5 2区医学 Q1 CLINICAL NEUROLOGY

Cephalalgia Pub Date : 2024-07-01 Epub Date: 2024-07-21 DOI:10.1177/03331024241261077

Ruth Ruscheweyh, Stefanie Förderreuther, Tobias Freilinger, Charly Gaul, Gudrun Goßrau, Tim Patrick Jürgens, Torsten Kraya, Lars Neeb, Victoria Ruschil, Jörg Scheidt, Thomas Dresler

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引用次数: 0

摘要

背景：偏头痛残疾评估（MIDAS）被广泛使用。然而，关于 MIDAS 分数的降低在多大程度上表明对患者而言发生了重要变化的数据却很有限：方法：采用德国偏头痛和头痛协会（DMKG）头痛登记处的数据，以患者全球变化印象（PGIC）为锚，应用平均变化和接收器操作特征曲线方法，确定 MIDAS 的最小重要差异（MID）：共纳入1218名成年偏头痛患者（85.6%为女性，40.2 ± 12.8岁，基线MIDAS 44.2 ± 47.4，随访MIDAS 36.5 ± 45.3）。对于基线 MIDAS >20（MIDAS IV 级，n = 757）的患者，以 PGIC "有所改善 "为锚的不同方法得出的 MIDAS 百分比变化 MID 在 -29.4% 和 -33.2% 之间。对于基线值在 6 到 20 之间的 MIDAS（II 级和 III 级，n = 334），以 PGIC "大有改进 "为锚，差异变化中值介于-3.5 到-4.5 点之间：基于上述结果，我们估计在三级头痛治疗人群中，基线MIDAS大于20的患者的MIDAS为-30%，基线MIDAS为6-20的患者的MIDAS为-4点：DMKG头痛注册中心已在德国临床试验注册中心注册（DRKS 00021081）。

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Minimal important difference of the Migraine Disability Assessment (MIDAS): Longitudinal data from the DMKG Headache Registry.

Background: The Migraine Disability Assessment (MIDAS) is widely used. However, there are limited data on how much a reduction in the MIDAS score indicates a change that matters to the patient.

Methods: Data from the DMKG (i.e. German Migraine and Headache Society) Headache Registry were used to determine the minimal important difference (MID) of the MIDAS, using the Patient Global Impression of Change (PGIC) as anchor and applying average change and receiver operating characteristic curve methods.

Results: In total, 1218 adult migraine patients (85.6% female, 40.2 ± 12.8 years, baseline MIDAS 44.2 ± 47.4, follow-up MIDAS 36.5 ± 45.3) were included. For patients with baseline MIDAS >20 (MIDAS grade IV, n = 757), different methods using PGIC "somewhat improved" as anchor yielded percent change MIDs of the MIDAS between -29.4% and -33.2%. For baseline MIDAS between 6 and 20 (grades II and III, n = 334), using PGIC "much improved" as anchor, difference change MIDs were between -3.5 and -4.5 points.

Conclusions: Based on the above results, we estimated the MID of the MIDAS at -30% for patients with a baseline MIDAS >20, and at -4 points for those with a baseline MIDAS of 6-20, for a tertiary headache care population.

Trial registration: The DMKG Headache Registry is registered with the German Clinical Trials Register (DRKS 00021081).

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来源期刊

Cephalalgia 医学-临床神经学

CiteScore

10.10

自引率

6.10%

发文量

108

审稿时长

4-8 weeks

期刊介绍： Cephalalgia contains original peer reviewed papers on all aspects of headache. The journal provides an international forum for original research papers, review articles and short communications. Published monthly on behalf of the International Headache Society, Cephalalgia''s rapid review averages 5 ½ weeks from author submission to first decision.