糖精:含糖的抗菌剂。

IF 12.1 1区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
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引用次数: 0

摘要

糖基化细菌素(又称糖肽)于 2011 年首次被发现。这些生物活性肽由细菌产生,以获得生存优势。它们具有不同类型的聚糖,并表现出不同的抗菌活性。目前,在实验中已知的糖苷酶有 13 种,在不同细菌门中硅学鉴定出的糖苷酶超过 250 种。值得注意的是,糖苷酶因其聚糖介导的抗菌活性而得到认可,被证明对耐药性病原体和食源性病原体有效。许多糖苷球蛋白都含有罕见的 S 键聚糖。糖基转移酶(GTs)负责将糖转移到糖苷中,并参与糖苷的生物合成,它们通常在生产者的基因组中聚集在一起。这种聚类使它们对于具有不同底物特异性的定制糖工程非常有价值。糖苷酶的异源表达为各行各业建立糖肽和糖共轭物生产微生物工厂铺平了道路。在这篇综述中,我们强调了完全和部分表征的糖苷酶及其糖基化酶的主要作用。此外,我们还探讨了特定的聚糖结构如何促进这些功能在抗菌活动中的发挥。此外,我们还讨论了旨在利用细菌糖生物学开发食品防腐剂以及替代或补充传统抗生素的新方法和日益增加的努力,尤其是在面对抗生素耐药性致病菌的情况下。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
GLYCOCINS: The sugar peppered antimicrobials

Glycosylated bacteriocins, known as glycocins, were first discovered in 2011. These bioactive peptides are produced by bacteria to gain survival advantages. They exhibit diverse types of glycans and demonstrate varied antimicrobial activity. Currently, there are 13 experimentally known glycocins, with over 250 identified in silico across different bacterial phyla. Notably, glycocins are recognized for their glycan-mediated antimicrobial activity, proving effective against drug-resistant and foodborne pathogens. Many glycocins contain rare S-linked glycans. Glycosyltransferases (GTs), responsible for transferring sugar to glycocins and involved in glycocin biosynthesis, often cluster together in the producer's genome. This clustering makes them valuable for custom glycoengineering with diverse substrate specificities. Heterologous expression of glycocins has paved the way for the establishment of microbial factories for glycopeptide and glycoconjugate production across various industries. In this review, we emphasize the primary roles of fully and partially characterized glycocins and their glycosylating enzymes. Additionally, we explore how specific glycan structures facilitate these functions in antibacterial activities. Furthermore, we discuss newer approaches and increasing efforts aimed at exploiting bacterial glycobiology for the development of food preservatives and as replacements or complements to traditional antibiotics, particularly in the face of antibiotic-resistant pathogenic bacteria.

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来源期刊
Biotechnology advances
Biotechnology advances 工程技术-生物工程与应用微生物
CiteScore
25.50
自引率
2.50%
发文量
167
审稿时长
37 days
期刊介绍: Biotechnology Advances is a comprehensive review journal that covers all aspects of the multidisciplinary field of biotechnology. The journal focuses on biotechnology principles and their applications in various industries, agriculture, medicine, environmental concerns, and regulatory issues. It publishes authoritative articles that highlight current developments and future trends in the field of biotechnology. The journal invites submissions of manuscripts that are relevant and appropriate. It targets a wide audience, including scientists, engineers, students, instructors, researchers, practitioners, managers, governments, and other stakeholders in the field. Additionally, special issues are published based on selected presentations from recent relevant conferences in collaboration with the organizations hosting those conferences.
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