替代剪接调控中的 RNA 结构:从机制到治疗。

IF 3.3 2区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Nengcheng Bao, Zhechao Wang, Jiayan Fu, Haiyang Dong, Yongfeng Jin
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引用次数: 0

摘要

替代剪接是一个高度复杂的过程,在转录后调控中发挥着关键作用,并极大地扩展了真核生物中数量有限的编码基因的功能蛋白质组。其调控是多因素的,RNA 结构对其有重要影响。RNA 构象异常会导致剪接模式失调,从而直接影响疾病症状的表现。本综述总结了 RNA 二级结构介导的剪接调控的分子机制,重点探讨了异常 RNA 构象与剪接缺陷导致的疾病表型之间复杂的相互作用。本研究还探讨了重塑结构构象的其他因素,丰富了我们对结构介导的剪接调控机制网络的理解。此外,研究还强调了针对人类疾病中异常剪接校正的临床作用。文章描述了这一现象背后的主要作用机制,随后讨论了未来的发展战略和相关挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
RNA structure in alternative splicing regulation: from mechanism to therapy.

Alternative splicing is a highly intricate process that plays a crucial role in post-transcriptional regulation and significantly expands the functional proteome of a limited number of coding genes in eukaryotes. Its regulation is multifactorial, with RNA structure exerting a significant impact. Aberrant RNA conformations lead to dysregulation of splicing patterns, which directly affects the manifestation of disease symptoms. In this review, the molecular mechanisms of RNA secondary structure-mediated splicing regulation are summarized, with a focus on the complex interplay between aberrant RNA conformations and disease phenotypes resulted from splicing defects. This study also explores additional factors that reshape structural conformations, enriching our understanding of the mechanistic network underlying structure-mediated splicing regulation. In addition, an emphasis has been placed on the clinical role of targeting aberrant splicing corrections in human diseases. The principal mechanisms of action behind this phenomenon are described, followed by a discussion of prospective development strategies and pertinent challenges.

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来源期刊
Acta biochimica et biophysica Sinica
Acta biochimica et biophysica Sinica 生物-生化与分子生物学
CiteScore
5.00
自引率
5.40%
发文量
170
审稿时长
3 months
期刊介绍: Acta Biochimica et Biophysica Sinica (ABBS) is an internationally peer-reviewed journal sponsored by the Shanghai Institute of Biochemistry and Cell Biology (CAS). ABBS aims to publish original research articles and review articles in diverse fields of biochemical research including Protein Science, Nucleic Acids, Molecular Biology, Cell Biology, Biophysics, Immunology, and Signal Transduction, etc.
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