利用多光谱漫反射光学成像对转化区进行无标记评估,以实现宫颈癌的早期检测。

IF 2 3区 物理与天体物理 Q3 BIOCHEMICAL RESEARCH METHODS
J. Karthika, Arpitha Anantharaju, Dhanush Koodi, Hardik J. Pandya, Uttam M. Pal
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引用次数: 0

摘要

评估转化区是诊断宫颈癌的关键一步。本研究开发了一种便携式、无标记的经阴道多光谱漫反射光学成像(MDOI)探头,用于评估转化区。图像采集自 N = 5(N = 1 名正常患者、N = 2 名恶性肿瘤前期患者和 N = 2 名恶性肿瘤患者)患者。与正常患者(450 纳米为 0.13,545 纳米为 0.14)相比,恶性肿瘤前期患者在 545 纳米和 450 纳米的光谱对比度 (ρ)等关键参数更高(450 纳米为 0.29,0.25;545 纳米为 0.30,0.17)。光谱强度比 R610/R450 和 R610/R545 的阈值也可分别作为与新的和原有的鳞状柱状交界处(SCJ)相关的标记。该试验研究强调了光谱对比度(ρ)和光谱强度比(R610/R450 和 R610/R545)图像等新标记的使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Label-free assessment of the transformation zone using multispectral diffuse optical imaging toward early detection of cervical cancer

Label-free assessment of the transformation zone using multispectral diffuse optical imaging toward early detection of cervical cancer

The assessment of the transformation zone is a critical step toward diagnosis of cervical cancer. This work involves the development of a portable, label-free transvaginal multispectral diffuse optical imaging (MDOI) imaging probe to estimate the transformation zone. The images were acquired from N = 5 (N = 1 normal, N = 2 premalignant, and N = 2 malignant) patients. Key parameters such as spectral contrast ratio (ρ) at 545 and 450 nm were higher in premalignant (0.29, 0.25 for 450 nm and 0.30, 0.17 for 545 nm) as compared to the normal patients (0.13 and 0.14 for 450 and 545 nm, respectively). The threshold for the spectral intensity ratio R610/R450 and R610/R545 can also be used as a marker to correlate with the new and original squamous columnar junction (SCJ), respectively. The pilot study highlights the use of new markers such as spectral contrast ratio (ρ) and spectral intensity ratio (R610/R450 and R610/R545) images.

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来源期刊
Journal of Biophotonics
Journal of Biophotonics 生物-生化研究方法
CiteScore
5.70
自引率
7.10%
发文量
248
审稿时长
1 months
期刊介绍: The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.
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