体内反射共聚焦显微镜在鲍温氏病诊断中的应用。

IF 2 3区 工程技术 Q2 ANATOMY & MORPHOLOGY
Shu Ding, Lingxue Hu, Yu Rao, Ruijian Ren, Xiaoliang Tong, Aiyuan Guo, Jian Huang, Zhen Tang
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引用次数: 0

摘要

鲍温氏病(Bowen's disease,BD)是一种较为罕见的早期鳞状细胞原位癌,多发于中老年人,好发于身体各部位的皮肤或黏膜。其发病隐匿,病程慢性,部分患者在皮肤外有恶性肿瘤,因此有必要对该病进行早期诊断和评估。本研究旨在探讨反射共聚焦显微镜(RCM)在 BD 诊断中的应用。我们对 92 例临床初步诊断为 BD 的患者的皮损部位进行了反射共聚焦显微镜成像,并进行了皮肤活检以进行组织学诊断。对 RCM 结果和组织学检查的回顾性分析显示,在对 RCM 图像进行分析后,92 例活组织检查病变中有 61 例被诊断为 BD,其中 54 例与 RCM 诊断一致。在 59 例经 RCM 诊断为 BD 的病例中,有 54 例与组织学诊断一致。随后,我们分析了经活检证实的 BD 患者的 RCM 特征,并比较了两种不同病变(典型鲍温氏病和色素性鲍温氏病)的 RCM 图像,进一步总结了 RCM 下 BD 的要点。最后,我们重点讨论了 BD 与其他皮肤病在 RCM 中的鉴别特征。RCM 在诊断 BD 方面具有重要价值。研究亮点:对临床诊断为 BD 的患者进行 RCM 和组织学诊断的回顾性研究。分析经活检验证的皮损的 RCM 特征。RCM 在诊断和鉴别 BD 方面具有重要价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Application of in vivo reflectance confocal microscopy in the diagnosis of Bowen's disease.

Bowen's disease (BD) is a relatively rare early-stage squamous cell carcinoma in situ, most commonly affecting the middle-aged and elderly, and occurring on the skin or mucous membranes of various parts of the body. Its onset is concealed, the course of the disease is chronic, and some patients have malignant tumors outside the skin; therefore, it is necessary to diagnose and evaluate the disease at an early stage. This study aimed to investigate the application of reflectance confocal microscopy (RCM) in the diagnosis of BD. We performed RCM imaging on the lesion site and underwent skin biopsy for histological diagnosis of 92 patients initially diagnosed with BD in clinic. A retrospective analysis of the RCM result as well as the histological examination revealed that after analyzing RCM images, out of 92 biopsy lesions, 61 were diagnosed with BD, of which 54 were consistent with RCM diagnosis. Among the 59 cases diagnosed with BD by RCM, 54 cases were consistent with the histological diagnosis. Afterwards, we analyzed the RCM characteristics in patients with BD verified by biopsy, and compared the RCM images of two different lesions, classic Bowen's disease and pigmented Bowen's disease, and further summarized the key points of BD under RCM. Finally, we focused on the differential characteristics between BD and other skin diseases in RCM. RCM is of great value in the diagnosis of BD. RESEARCH HIGHLIGHTS: A retrospective study of RCM and histological diagnosis in patients with clinical diagnosis of BD. Analyze the RCM characteristics of skin lesions verified by biopsy. RCM is of great value in the diagnosis and differentiation of BD.

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来源期刊
Microscopy Research and Technique
Microscopy Research and Technique 医学-解剖学与形态学
CiteScore
5.30
自引率
20.00%
发文量
233
审稿时长
4.7 months
期刊介绍: Microscopy Research and Technique (MRT) publishes articles on all aspects of advanced microscopy original architecture and methodologies with applications in the biological, clinical, chemical, and materials sciences. Original basic and applied research as well as technical papers dealing with the various subsets of microscopy are encouraged. MRT is the right form for those developing new microscopy methods or using the microscope to answer key questions in basic and applied research.
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