健康与退休研究》中估计的脉搏波速度与痴呆症的高风险有关。

IF 3.2 3区 医学 Q2 PERIPHERAL VASCULAR DISEASE
Kevin S Heffernan, Janet M Wilmoth, Andrew S London
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引用次数: 0

摘要

背景:在本文中,我们利用健康与退休研究(HRS)来研究脉搏波速度(ePWV)估算值与无痴呆症和痴呆症认知障碍之间的关系:我们利用 8,492 名男性和女性(平均年龄 68.6岁)的数据建立了ePWV与认知状况之间的关系模型,并对年龄、血压、社会人口和社会经济特征(性别、种族和民族、教育、收入、财富)、健康行为(吸烟和体育锻炼)、体重指数(BMI)进行了控制、健康状况和相关药物使用(心血管疾病、糖尿病和中风病史),以及与脑血管疾病(CVD)相关的生物标志物(C 反应蛋白、胱抑素-C、血红蛋白 A1c、总胆固醇、高密度脂蛋白 [HDL] 胆固醇)。ePWV 是根据参与者的年龄和静息血压计算得出的:结果:在控制 ePWV 组成成分(年龄、年龄平方、收缩压和舒张压)的模型中,相对于无认知障碍或痴呆的组别,ePWV 与认知障碍但无痴呆(OR=2.761)和痴呆(OR=6.344)的几率增加相关。在控制了 ePWV 的组成成分、社会人口和社会经济特征、健康状况和用药情况、健康行为、体重指数和心血管疾病相关生物标志物后,ePWV 仍与痴呆(OR=3.969)显著相关,但与无痴呆的认知障碍(OR=1.782)无关:这些研究结果表明,ePWV可能是一种新的研究工具和血管老化的生物标志物,可用于大型、具有人口代表性的研究,以检查认知老化和痴呆风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Estimated Pulse Wave Velocity Is Associated With a Higher Risk of Dementia in the Health and Retirement Study.

Background: In this paper, we use the Health and Retirement Study (HRS) to examine the relationship between an estimated measure of pulse wave velocity (ePWV) and cognitive impairment with no dementia and dementia, respectively.

Methods: We modeled the relationship between ePWV and cognitive status in 2006/2008 using data from 8,492 men and women (mean age 68.6 years) controlling for age, blood pressure, sociodemographic, and socioeconomic characteristics (sex, race and ethnicity, education, income, wealth), health behaviors (smoking and physical activity), body mass index (BMI), health status and related medication use (history of cardiovascular disease, diabetes, and stroke), and cerebrovascular disease (CVD)-related biomarkers (C-reactive protein, cystatin-C, hemoglobin A1c, total cholesterol, high-density lipoprotein [HDL] cholesterol). We assess cognitive function with the 27-item Langa-Weir Telephone Interview for Cognitive Status (TICS) scale. ePWV is derived from an equation based on participant age and resting blood pressure.

Results: In a model that controlled for the constituent components of ePWV (age, age squared, systolic and diastolic blood pressure), ePWV is associated with increased odds of having cognitive impairment with no dementia (OR = 2.761) and dementia (OR = 6.344) relative to a group with no cognitive impairment or dementia. After controlling for the constituent components of ePWV, sociodemographic and socioeconomic characteristics, health behaviors, BMI, health status and medication use, and CVD-related biomarkers, ePWV remains significantly associated with dementia (OR = 3.969) but not cognitive impairment with no dementia (OR = 1.782).

Conclusions: These findings suggest that ePWV may be a novel research tool and biomarker of vascular aging that can be used in large, population-representative studies to examine cognitive aging and dementia risk.

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来源期刊
American Journal of Hypertension
American Journal of Hypertension 医学-外周血管病
CiteScore
6.90
自引率
6.20%
发文量
144
审稿时长
3-8 weeks
期刊介绍: The American Journal of Hypertension is a monthly, peer-reviewed journal that provides a forum for scientific inquiry of the highest standards in the field of hypertension and related cardiovascular disease. The journal publishes high-quality original research and review articles on basic sciences, molecular biology, clinical and experimental hypertension, cardiology, epidemiology, pediatric hypertension, endocrinology, neurophysiology, and nephrology.
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